Clinical Trials

Efficacy and Safety of Levetiracetam Versus Placebo on Levodopa-Induced Dyskinesias in Advanced Parkinson's Disease

Disrupted Neurotransmitter Function, Dyskinesia, Etiology
Dresden University of Technology
Parkinson's Disease
Drug
levetiracetam
The study is designed to measure the efficacy and safety of levetiracetam on levodopa-induced dyskinesias in late-stage Parkinson's disease. The patients are planned to be treated with levetiracetam Responses: 0 ... 

Sarizotan in the Treatment of Neuroleptic-Induced Tardive Dyskinesia

Dopamine-Based Approaches, Dyskinesia, Cognitive Symptoms, Serotonin-Based Approaches
Centre for Addiction and Mental Health
Neuroleptic-Induced Tardive Dyskinesia
Drug
Sarizotan
TD is a troublesome and potentially irreversible side effect associated with the use of neuroleptics. While the newer neuroleptics are improved in this regard, they all still carry the Responses: 0 ... 

Observational Study of Pergolide Mesylate and Cardiac Valvulopathy

Dopamine-Based Approaches, Treatment-Related Complications
Eli Lilly and Company
Parkinson Disease
The primary objective of this study is to estimate the incidence of new-onset valvulopathy, determined by baseline and follow-up echocardiograms, in patients with Parkinson's Disease who are Responses: 0 ... 

The Therapeutics Effects of Yoga in Individuals With Parkinson's Disease

Behavioral Approaches
University of Kansas
Parkinson's Disease
Behavioral
Yoga Training
To determine if yoga is beneficial in improving physical function quality of life and medical status in people with Parkinson's disease Responses: 0 ... 

Sarizotan in Parkinson Patients With L-Dopa-Induced Dyskinesia

Dopamine-Based Approaches, Dyskinesia, Serotonin-Based Approaches
Merck KGaA
Parkinson's Disease
Drug
Sarizotan HCl
The primary purpose of the study is to investigate the anti-dyskinetic effect of several doses of sarizotan in Parkinson patients in order to generate information on the dose-response relationship Responses: 0 ... 

Development of Imaging, Clinical and Biochemical Bio-Markers for Parkinson's Disease

Clinical Scales, Imaging, Biochemical Biomarkers, Biomarkers
Institute for Neurodegenerative Disorders
Parkinson's Disease
Procedure
[123I]β-CIT and SPECT imaging
We propose to build on preliminary data evaluating non-dopaminergic/non-motor clinical biomarkers to more fully assess these markers at the threshold of Parkinson disease (PD). Responses: 0 ... 

Laser Light Cues for Gait Freezing in Parkinson's Disease

Postural & Gait Disturbances
Beth Israel Deaconess Medical Center
Parkinson's Disease
Device
Laser Cane and U-Step Walker with Laser Accessory
The purpose of this study is to gather data to see if the Laser Cane and/or U-Step Walker with laser accessory is more effective in aiding with gait freezing than a regular cane/U-Step Responses: 0 ... 

A Study of T2000 in Essential Tremor

Taro Pharmaceuticals USA
Essential Tremor
Drug
T2000
This study will evaluate the safety and efficacy of T2000 when used to treat patients with moderate to severe essential tremor over a 20 week period. Essential tremor (ET) is a common form of Responses: 0 ... 

Study of (Mirapex) Pramipexole for the Early Treatment of Parkinsons Disease

Dopamine-Based Approaches
Boehringer Ingelheim Pharmaceuticals
Parkinson Disease
Drug
pramipexole
This is a double blind, placebo-controlled clinical trial of 15 months duration designed to examine early Mirapex (pramipexole) treatment vs. delayed Mirapex (pramipexole) treatment in Responses: 0 ... 

Sensory Cues for Freezing in Parkinson's Disease

Postural & Gait Disturbances
Austin Health
Parkinson's Disease
Device
Sensory Cueing Device
The purpose of this study is (1) to determine if patient triggered sensory(auditory, visual and tactile) cues can help treat freezing of gait in Parkinson's disease, and (2) to assess if unexpected Responses: 0 ...