What are the potential PD subtypes, and how do they differ clinically and/or genetically?

Clinical Features, PD Subtypes, Clinical & Biological Features

There is some evidence that different forms of Parkinson's disease exist and that the severity of disease course may be linked to these possible subtypes. To date, there is little understanding of what differentiates these patient populations from one another, either clinically or pathologically. Is there evidence for a genetic link? What are the clinical differences?

Responses:
Subtypes -what would you do?
Katie Hood, MJFF
18 Jun 2009 09:16 PM EST
As anyone who knows me knows, this is something I'm fascinated by. ... 
LRRK2 G2019S mutation produces a clinical spectrum that lends itself to detailed analyses
Susan Bressman, Beth Israel
19 Jun 2009 05:59 PM EST
With gene identification we have an opportunity to perform “genotype-phenotype” correlations and determine if specific mutations are associated with particular subtypes. For the most ... 
Responses: 2
Clinical PD subtypes: tremor-dominant and postural-instability-gait-difficulty (PIGD)
Joseph Jankovic, Baylor
22 Jun 2009 08:11 AM EST
Together with my colleagues at Baylor we first proposed two major subtypes of PD, tremor-dominant and postural-instability-gait-difficulty (PIGD) in 1985 and this observation was confirmed when ... 
PD clinical subtypes
Thomas G Beach, Sun Health
30 Jun 2009 01:21 PM EST
If we use as a model those neurodegenerative diseases caused by single gene mutations, such as FTDP-17 (tau gene mutations), FTLD-TDP (progranulin gene mutations), LRRK2 mutations, APP mutations, ... 
PD subtypes: First thing you do - katie....
Haydeh Payami, Wadsworth
3 Jul 2009 07:54 AM EST
katie:  first thing i would do is apply the subtype information to clinical trials.   if we tried the right drug on the right patients, we would be more successful with drug ... 
Is there a parkin clinical subtype?
Holli Kawadler, MJFF
7 Jul 2009 02:31 PM EST
Patients with parkin mutations often exhibit specific phenotypic characteristics (early-onset, slow progression, and the absence of Lewy body pathology), suggesting possible differences in pathogenic ... 
Heterogeneous phenotypes from autosomal dominant mutations are not uncommon
John Q Trojanowski, UPENN
15 Jul 2009 09:33 AM EST
Autosomal dominant genetic mutations that are pathogenic for neurodenegerative diseases, like those in genes that cause PD, AD, FTLD, ALS and other disorders, are powerful drivers of the disease ...