MJFF Asks: What should the next funding program on PD Subtypes look like?

PD Subtypes

What are the next practical steps for identifying Parkinson’s disease subtypes that can be useful in guiding treatment and therapeutic development?

This question arose from discussion at a recent MJFF Executive Scientific Advisory Board meeting of the outcomes from the Foundation's '2007 PD Subtypes Program'. Read more details here. Members can post all comments and questions by hitting the 'create response' button on this research question. MJFF will summarize and announce the conclusions of this effort after sufficient discussion has taken place.

Responses:
Summary of previous MJFF PD Subtypes Program
Todd Sherer, MJFF
25 Aug 2009 08:49 AM EST
In response to this RFI, it is worth mentioning that the MJFF has been investing in efforts to better define PD subtypes for the last few years. In 2007, we launched a ‘PD Subtypes’ ... 
PD subtypes: MJFF really needs your input
Todd Sherer, MJFF
26 Oct 2009 03:23 PM EST
The MJFF has identified improving the understanding of PD subtypes as a priority research area for 2010.  Improving our understanding of PD subtypes can directly optimize the use of current PD ... 
PD subtyping focusing on movement basics
Alberto J Espay, UC
28 Oct 2009 04:36 PM EST
Among the benefits of enhancing our knowledge on PD subtyping are the better focusing of target populations for clinical trials. At stake is who may and may not ... 
Parsing of non-motor subtypes: inspired by Alberto Espay's post
Michael T Rogan
12 Nov 2009 03:50 PM EST
Alberto Espay posted about how PD diagnostic categories can gloss over the phenotypic complexity of movement and therefore hide the possible presence of disease subtypes.  Is this also true ... 
Responses: 1
Supplement to PD Subtypes RFI: Related discussion on PD Online
Michael T Rogan
12 Nov 2009 05:35 PM EST
In addition to the discussion going on about the MJFF PD Subtypes funding program, here are 10 other recent PD Online posts about PD Subtypes, by: ... 
Are there relevant PD subtypes?
Holly A Shill, Sun Health, et al.
19 Nov 2009 03:11 PM EST
In practicality most people are in between tremor dominant and PIGD, so maybe the better question is whether there are PD subtypes relevant for PD therapeutic development. ... 
PD subtypes as orphan diseases?
alfred stracher, SUNY Downstate
24 Nov 2009 03:05 PM EST
The delineation of PD into subtypes may have some commercial and/or grant funding advantages since the subtypes may be classified as "orphan diseases" which place them in  a different funding ... 
gene-drug interaction may define subtypes
Haydeh Payami, Wadsworth
23 Dec 2009 06:00 PM EST
I think the answer is yes, and here is evidence. Part of this work was presented at the XVIII WFN World Congress on Parkinson's Disease and Related Disorders. ABSTRACT ...