How do parkin and PINK1 influence mitochondrial function?

PARK2 (Parkin), Targeting Mitochondrial Dysfunction, Mitochondrial Dysfunction , PARK6 (PINK1)

Parkin and PINK1 are two genes implicated in autosomal recessive Parkinson's disease. Parkin is an E3 ligase and a component of the ubiquitin-proteasome system involved in protein turnover while the function of PINK1 is still unclear. Biochemical studies have linked the two in a molecular pathway that entail mitochondrial function, yet how parkin and PINK1 interact, and how these two proteins affect mitochondrial function remains a mystery.

Responses:
Mitochondrial Dynamics: Is there Parkin' in the PINK1 Zone?
Charleen T Chu, PITT
5 May 2009 02:32 PM EST
Two recent studies (Dagda et al., 2009; Narendra et al., 2008) indicate that PINK1 and Parkin may promote a similar steady state phenotype of healthy mitochondrial networks by acting at different ... 
Responses: 1
Function of PINK1 and importance of substrate identification
Janetta G Culvenor, et al.
28 Jul 2009 12:22 AM EST
PINK1 was discovered as a PD genetically linked gene in 2004. We still do not know the role of this protein kinase in metabolic pathways. Since mutations are recessively inherited and knock-out or ... 
The PINK1/parkin connection: Probably more than just a linear pathway
Konstanze F Winklhofer, LMU
31 Aug 2009 10:06 AM EST
There is increasing evidence that PD-associated genes directly or indirectly impinge on mitochondrial integrity, thereby providing a link to pathopysiological alterations observed in sporadic PD. ... 
How are Parkin, PINK1 and HtrA2/Omi interconnected?
Sonal S Das, MJFF
21 Sep 2009 05:59 PM EST
Defects in mitochondrial function are inextricably linked to Parkinson’s disease progression and may represent initial stages of disease pathogenesis (Plun-Favreau, et al 2008).  Indeed, ... 
Responses: 1
PINK1, TRAP1, HtrA2/Omi, Parkin: Convergence on mitochondrial quality control?
Charleen T Chu, PITT
24 Sep 2009 10:22 AM EST
Recently accelerating studies on PINK1 and its potential relationships to TRAP1, HtrA2/Omi and Parkin begin to paint a picture of a network of pathways converging on mitochondrial quality ... 
Parkin, PINK1 and mitochondrial turnover
Holli Kawadler, MJFF
7 Dec 2009 05:21 PM EST
New findings published today in PNAS further support the role of PINK1 and parkin in mitochondrial quality control discussed by Dr. Chu in her post. Vives-Bauza et al. demonstrate that parkin, in a ... 
Emerging Cellular Function of PINK1-Parkin Pathway in the Removal of Damaged Mitochondria by Mitophagy
X W Yang, UCLA
28 Feb 2010 10:35 PM EST
Recessive Parkinson's disease (PD) genes Parkin and PINK1 have been placed genetically in the same molecular pathway that is essential to maintain the integrity and function of ... 
Mitofusin: the link between parkin, PINK1 and mitophagy?
Alexander J Whitworth, Sheffield
4 Mar 2010 02:36 PM EST
A recent spate of papers on the functional relationship of PINK1 and parkin, and their involvement in autophagic degradation of mitochondria (mitophagy), have begun to illuminate our understanding of ...