How do parkin and PINK1 influence mitochondrial function?
Parkin and PINK1 are two genes implicated in autosomal recessive Parkinson's disease. Parkin is an E3 ligase and a component of the ubiquitin-proteasome system involved in protein turnover while the function of PINK1 is still unclear. Biochemical studies have linked the two in a molecular pathway that entail mitochondrial function, yet how parkin and PINK1 interact, and how these two proteins affect mitochondrial function remains a mystery.
Responses:
Mitochondrial Dynamics: Is there Parkin' in the PINK1 Zone?
5 May 2009 02:32 PM EST
Responses: 1
Function of PINK1 and importance of substrate identification
28 Jul 2009 12:22 AM EST
The PINK1/parkin connection: Probably more than just a linear pathway
31 Aug 2009 10:06 AM EST
How are Parkin, PINK1 and HtrA2/Omi interconnected?
21 Sep 2009 05:59 PM EST
Responses: 1
PINK1, TRAP1, HtrA2/Omi, Parkin: Convergence on mitochondrial quality control?
24 Sep 2009 10:22 AM EST
Parkin, PINK1 and mitochondrial turnover
7 Dec 2009 05:21 PM EST
Emerging Cellular Function of PINK1-Parkin Pathway in the Removal of Damaged Mitochondria by Mitophagy
28 Feb 2010 10:35 PM EST
Mitofusin: the link between parkin, PINK1 and mitophagy?
4 Mar 2010 02:36 PM EST
