How can the adaptive immune system be targeted as a therapeutic approach for PD?

Neuroinflammatory Responses, Neuroimmune Signaling Pathways, Neuroimmune Function, Targeting Neuroimmune Dysfunction

Neuroinflammation is proposed to be a major factor in creating a toxic environment in the PD brain. However, what is the contribution of the adaptive immune system (ie. T cell function) to PD pathogenesis, and how can we target this system for future therapeutic approaches?

 

Responses:
Microglia and alpha-synuclein
Carolina Cebrian, Columbia
3 Feb 2010 11:58 PM EST
Parkinson’s disease (PD) is mainly characterized by a loss of the dompaniergic cells located in the midbrain’s substantia nigra pars compacta. In addition to this neuronal loss, PD is ... 
Immunotherapy for Parkinson's disease: Mechanisms and pathways for human use
Howard Gendelman, et al.
4 Mar 2010 11:17 AM EST
The therapeutic approach is based on the notion that the inciting event that underlies the pathogenesis of Parkinson’s disease (PD) is the accumulation of aggregated proteins within neuronal ...