Treatment-Related Complications

PD patients can be adversly affected by both symptoms of the disease and side effects of therapies that target symptoms.  Some of the most onerous adverse conditions seen in PD patients, such as dyskinesia, are known to be side effects of drug therapies that aim at reducing the effects of the dopamine depletion that occurs in PD. Other treatment-related complications of dopamine replacement therapies include on-off fluctuations and loss of drug efficacy with chronic treatment ('wearing off').   Psychiatric side effects are also associated with PD drug therapies.

 

Contributions:
Conflict of clinical goals and research goals in clinical trials
The challenges of clinical trial design in PD therapeutics development: what are the strengths and weaknesses of novel and traditional approaches?
Holli Kawadler, MJFF
29 Oct 2009
Much of the discussion of clinical trials thus far has involved trial design (ie., discussion of the delayed-start design of the recent ADAGIO trial). But an article in the NYT brought my attention ... 
Heavy L-DOPA may lighten dyskinesias
Hot Topics@SfN 2009
Michael T Rogan
20 Oct 2009
In SfN poster # 629.7, Torun Malmlof et al. report new data on their use of L-DOPA synthesized with deuterium (heavy hydrogen). Deuteriation generally acts to retard normal metabolic processes, and ... 
News:
Impax Pharmaceuticals Announces Presentation of IPX066 Phase II Data at 13th International Congress of Parkinson's Disease and Movement Disorders
Impax Pharmaceuticals, the brand products division of Impax Laboratories, Inc. (NASDAQ: IPXL) today announced the positive interim results from a recent Phase II trial of its late-stage drug ... 
08 Jun 2009
Related Clinical Trials:
Observational Study of Pergolide Mesylate and Cardiac Valvulopathy
31 May 2009
The primary objective of this study is to estimate the incidence of new-onset valvulopathy, determined by baseline and follow-up echocardiograms, in patients with Parkinson's Disease who are ... 
Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease
08 Dec 2008
This study will be conducted to study the effect of Desmopressin on the nocturnal micturition frequency in patients with idiopathic Parkinson syndrome. ... 
Body Weight Gain, Parkinson, Subthalamic Stimulation
12 Sep 2007
Chronic bilateral subthalamic stimulation leads a spectacular clinical improvement in patients with motor complications. However, the post-operative body weight gain involved may limit ... 
more
Related Citations:
Mechanisms Underlying Dopamine-Mediated Reward Bias in Compulsive Behaviors
19 Jan 2010
 ... 
Mechanisms Underlying Dopamine-Mediated Reward Bias in Compulsive Behaviors
19 Jan 2010
 ...