Serotonin-Based Approaches

Pharmacological Approaches

While the standard serotonin-based therapies (SSRIs, SNRIs) are commonly used for mood and anxiety disorders that can manifest with PD as well as other diseases, the effectiveness of these treatments in PD remains unknown. A multi-site clinical trial, SAD-PD, is underway to determine the most effective treatments for PD-depression. The serotonin system has also been investigated as a target for treatment of side effects such as the dyskinesia that can result from dopamine replacement therapies (Carta et al., 2007).

Reference: 
Carta M, Carlsson T, Kirik D, Björklund A. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Brain. 2007;130(Pt 7):1819-33.
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Contributions:
Comment on Navailles et al. (2010): STN stimulation and L-DOPA treatment affects serotonin levels in vivo
Cognitive Symptoms
Thomas Wichmann, Emory
10 Feb 2010
There is increasing evidence for the hypothesis that Parkinson’s disease (PD) and antiparkinsonian treatments both alter serotonin levels in non-motor areas of the brain which may in turn ... 
Failure of ACADIA Pharmaceuticals Pimavanserin Phase III trial for PD Psychosis
A Study of the Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis
Brian K. Fiske, MJFF
09 Sep 2009
Last week, ACADIA reported initial results from its Phase III efficacy trial for pimavanserin (ACP-103) as a possible treatment for PD psychosis. Results did not meet the primary endpoint ... 
Related Clinical Trials:
Sarizotan in the Treatment of Neuroleptic-Induced Tardive Dyskinesia
31 May 2009
TD is a troublesome and potentially irreversible side effect associated with the use of neuroleptics. While the newer neuroleptics are improved in this regard, they all still carry the ... 
Sarizotan in Parkinson Patients With L-Dopa-Induced Dyskinesia
31 May 2009
The primary purpose of the study is to investigate the anti-dyskinetic effect of several doses of sarizotan in Parkinson patients in order to generate information on the dose-response relationship ... 
Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo
31 May 2009
Antidepressant medicines sometimes cause sexual side effects. The purpose of this study is to determine whether the sexual dysfunction sometimes caused by selective serotonin reuptake ... 
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