Psychiatric Symptoms

A number of psychiatric symptoms of PD have been characterized.

  • Depression is found in 36-50% of PD cases (mean), including major depression, minor depression, dysthymia, subsyndromal symptoms. 
  • PD also leads to increased anxiety symptoms in 66% of patients, including generalized anxiety disorder, panic, social phobia.

Some PD drug therapies are associated with psychiatric complications.

 

Contributions:
Quality of life in PD patients: Depression as a key determinant
World Congress on PD & Related Disorders
Franziska Richter, UCLA
16 Dec 2009
In several discussions at this WFN conference it was emphasized that non-motor symptoms are critical for the quality of life in patients. In the poster cited below, Lena and Meike found that the ... 
Treating depression in PD: Recent studies and ongoing clinical trials
MEMBERS' OPEN FORUM: for rapid-fire posting of your questions and comments.
Irene Richard, Rochester
12 Nov 2009
Depression is common in PD and antidepressant medications are frequently prescribed. However, until recently there has been little evidence upon which to base treatment decisions.  In recent ... 
Recognition of emotional prosody is disrupted after subthalamic nucleus deep brain stimulation in PD.
Hot Topics@SfN 2009
Amandine Berthet, et al.
20 Oct 2009
Previous studies have demonstrated that the recognition of facial emotions was impaired following subthalamic nucleus (STN) deep brain stimulation (DBS) in PD. These deficiencies have been related to ... 
more
Grant Opportunities:
Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (SBIR [R43/R44])
30 Jun 2009
The purpose of this PA is to encourage small businesses to develop technologies and approaches (i.e., novel ways to use new or existing technologies) that will enable researchers to better ... 
Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (STTR [R41/R42])
30 Jun 2009
The purpose of this FOA is to encourage small businesses to develop technologies and approaches (i.e., novel ways to use new or existing technologies) that will enable researchers to better ... 
Events:
The 3rd International Congress on Gait & Mental Function
08 Jun 2009
Washington, DC, USA ... 
News:
SPOTLIGHT Q&A: New Model of Nonmotor Symptoms of Parkinson's Disease
Dr. Gary Miller and Dr. Todd Sherer discuss Dr. Miller's new publication in the Journal of Neuroscience (published Jun 24), in which he describes a new VMAT2-deficient mouse model of the nonmotor ... 
23 Jun 2009
Foundation Awards $2 Million for Research on Cognitive and Mood Symptoms of Parkinson's Disease
10/14/2008 GRANT AWARD PRESS RELEASE This post was updated 10/29/2009. ... 
14 Oct 2008
Responses: 2
Related Clinical Trials:
Treating Sexual Dysfunction From Selective Serotonin Reuptake Inhibitor (SSRI) Medication: a Study Comparing Requip CR to Placebo
31 May 2009
Antidepressant medicines sometimes cause sexual side effects. The purpose of this study is to determine whether the sexual dysfunction sometimes caused by selective serotonin reuptake ... 
Healthcare Utilization and Functional Disability in Parkinson's Disease
31 May 2009
Parkinson's Disease (PD) is often thought of as affecting movement only. In fact, more than 40% of patients also have anxiety and/or depression. The goals of this study are: (1) to ... 
The Mood/Cognitive Effects of STN vs. GPi Deep Brain Stimulation in Parkinson's Disease
31 May 2009
The purpose of this trial is to study the mood and cognitive effects of deep brain stimulation in Parkinson's disease. ... 
more
Related Citations:
Mechanisms Underlying Dopamine-Mediated Reward Bias in Compulsive Behaviors
19 Jan 2010
 ... 
Mechanisms Underlying Dopamine-Mediated Reward Bias in Compulsive Behaviors
19 Jan 2010
 ...