Protein Misfolding & Aggregation
Protein aggregation is observed in a number of neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease. In PD, misfolded alpha-synuclein is found in aggregates. These protein aggregates are a characteristic clinical feature of PD, though it remains unclear whether protein aggregation is a protective measure or pathogenic mechanism. Dysfunction of molecular chaperones, which ordinarily function to prevent newly synthesized proteins from misfolding and aggregating, has also been hypothesized to play a role in PD.
Responses:
Hsp70 may link parkin activity to alpha-synuclein aggregation
10 Mar 2009 10:29 AM EST
Contributions:
Workgroups:
30 Jun 2009
10 Jun 2009
