PD Guide
Post-Translational Modification
Post-translational modifications such as S-nitrosylation and phosphorylation have been implicated as factors in PD as well as in other neurodegenerative disorders. Nitrosative stress is thought to negatively impact the normal functions of the endoplasmic reticulum, contributing to the accumulation of misfolded proteins (Uehara, 2007; Benhar et al., 2006). Phosphorylated and truncated forms of alpha-synuclein have also been implicated in PD.
Reference:
Uehara T. Accumulation of misfolded protein through nitrosative stress linked to neurodegenerative disorders. Antioxid Redox Signal. 2007;9(5):597-601.
Benhar M, Forrester MT, Stamler JS. Nitrosative stress in the ER: a new role for S-nitrosylation in neurodegenerative diseases. ACS Chem Biol. 2006;1(6):355-8.