Oxidative Stress
Image from NIA, NIHEvidence of oxidative damage has been observed in post mortem examination of brain tissue from sporadic PD patients (Jenner, 2003). A number of causes are hypothesized to contribute to increased oxidative stress: oxidized dopamine resulting in the generation of reactive oxygen species (ROS); reduction of glutathione levels in PD brain; and mitochondrial dysfunction leading to production of ROS. Observation of post mortem PD tissue has revealed increased iron (also associated with ROS) and activated mitochondria (DADPH) as evidence of increased oxidative stress.
Reference:
Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8.
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6 Nov 2009 07:32 AM EST
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10 Jun 2009
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