Oxidative Stress

Targeting Mitochondrial Dysfunction, Mitochondrial Dysfunction , Targeting Oxidative Stress, Stress Response Pathways, PARK7 (DJ-1)

Image from NIA, NIHImage from NIA, NIHEvidence of oxidative damage has been observed in post mortem examination of brain tissue from sporadic PD patients (Jenner, 2003). A number of causes are hypothesized to contribute to increased oxidative stress: oxidized dopamine resulting in the generation of reactive oxygen species (ROS); reduction of glutathione levels in PD brain; and mitochondrial dysfunction leading to production of ROS. Observation of post mortem PD tissue has revealed increased iron (also associated with ROS) and activated mitochondria (DADPH) as evidence of increased oxidative stress.

Reference: 
Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8.
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Responses:
Oxi-alpha to the rescue?
Daniela F Hernandez, Columbia
6 Nov 2009 07:32 AM EST
This week, in the Journal of Neurochemistry, Choi and colleagues report protection against oxidative stress (OS)-induced cell death by a novel gene, Oxi-alpha, which is expressed specifically in DA ... 
Contributions:
Dopamine, Alpha-synuclein, and autophagic cell death
How can oxidative stress contribute to alpha-synuclein pathology/toxicity? What oxidative modifications of alpha-synuclein are relevant to the PD pathogenic process?
Daniela F Hernandez, Columbia
04 Feb 2010
Elevated cytosolic DA levels have been shown to result in increased neurotoxicity in cellular models of PD (Mosharov et al., 2009). In a new study published in the Journal of Neuroscience Research, ... 
New support for an old hypothesis: Toxic dopamine metabolites are key players in neuronal loss in PD when the intrinsic protection mechanisms fail.
World Congress on PD & Related Disorders
Franziska Richter, UCLA
14 Dec 2009
P1.217 Decreased putamen aldehyde dehydrogenase in Parkinson disease D. Goldstein, P. Sullivan, C. Holmes, I. Kopin, M. Basile ... 
Summary of the scientific session at Udall 2009
Hot Topics@Udall 2009
James P Bennett Jr, VCU
24 Sep 2009
The scientific session of the 11th Annual Morris Udall Parkinson’s Center Conference had four speakers.  ... 
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Research Questions:
How can oxidative stress contribute to alpha-synuclein pathology/toxicity? What oxidative modifications of alpha-synuclein are relevant to the PD pathogenic process?
04 Feb 2010
There is evidence of oxidative damage in brains of PD patients and anti-oxidant therapies have been explored as disease-modifying therapies for PD. Alpha-synuclein aggregation - in the form of Lewy ... 
Responses: 2
Workgroups:
Genetic Models of Parkinson's Disease Group
10 Jun 2009
This group aims to promote interactions, collaborations and the exchange of ideas of those members interested in developing or characterizing genetic disease models, particularly mouse models. ... 
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