PD Guide

Neurotrophic Factors

Cell health and survival is promoted by trophic factors, which operate during development and adulthood. There is no strong evidence that PD is caused by a trophic factor deficiency, but neurotrophic factors are considered attractive as possible neurorestorative or neuroprotective therapeutics.  Identified neurotrophic factors include GDNF, Neurturin, Persephin, Artemin, CDNF, BDNF, FGF20, and Pleiotrophin.