Acetylcholine

Disrupted Neurotransmitter Function, Cholinergic-Based Approaches

Model of the Acetylcholine ReceptorCredit: Richard Law and Andrew McCammon, UCSD Courtesy: National Science FoundationModel of the Acetylcholine ReceptorCredit: Richard Law and Andrew McCammon, UCSD Courtesy: National Science FoundationThe dopamine system is strongly linked to the cholinergic system. Dopamine and acetylcholine are normally in a state of homeostatic balance in the basal ganglia. Dopamine depletion, as seen in PD, produces a state of cholinergic sensitivity and a syndrome of basal ganglia pathophysiology that is profoundly disruptive to motor function.

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