News

Related Research Questions

Open Forum: for rapid-fire posting of your questions and comments.
Not sure where to post your ideas? This is the place! ... 
Responses: 8
A Lentiviral System for Inducible Intracerebroventricular Delivery
The delivery of synthetic peptides or secreted recombinant proteins to the CNS is often accomplished by intracerebroventricular (ICV) administration. This method is especially problematic for ... 
Impact of species differences in therapeutic development
At an internal MJFF meeting today a panel of invited scientists discussed several topics, including the following: Moving from rodent to non-human primate models with potential therapeutic ... 
Is the Time Right for Gene Therapy?
A story in the New York Times today (After Setbacks, Small Successes for Gene Therapy by Gina Kolata) suggests a possible resurgence for gene therapy after a series of setbacks, including the ... 
Responses: 1
Seeking member input on new methods and protocol resources.
We are planning a way to organize methodological issues on PD Online - technical questions, problem solving, and members' views on best practices in the lab.  What kind of PD-related ... 
What are the best methods for testing the efficacy of novel neuroprotective therapeutics in pre-clinical models?
An important step in moving novel neuroprotective agents towards the clinic involves testing the efficacy of therapeutics in preclinical models.  Many different preclinical models are available ... 
Responses: 15
What are the biological and psychosocial mechanisms of the placebo response, and how can we manage and/or tap the placebo response in PD clinical trials?
As is the case in other diseases, the current gold standard methodology for testing the efficacy of experimental Parkinson’s disease therapeutics involves the placebo-controlled study ... 
Responses: 10
What are the benefits to sharing a pre-clinical research model, other than scientific collaboration?
Widespread availability of critical research tools is necessary for rapid progress in PD research. Researchers may find, however, that the process for doing so can be time-consuming. Distribution of ... 
Responses: 5
Can induced pluripotent stem cells be used to generate useful Parkinson's disease cell models?
The demonstration that forced expression of only a handful of genes can 'reprogram' adult human skin cells into induced pluripotent stem (iPS) cells (with properties of embryonic stem cells) has ... 
Responses: 7
How can we improve brain delivery of trophic factors? The Myth of Convection Enhanced Delivery?
The direct delivery of proteins and genes to the brain by surgical techniques is hampered by the limited diffusion of the molecules into the target area. Convection Enhanced Delivery utilizes ... 
Responses: 6