Related Research Questions

Which behavioral outcomes are relevant in rodent models of dyskinesia?
The development of rodent models of LID has improved our ability to conduct studies into the molecular mechanisms of LID as well as to screen new therapeutic strategies. However, it is much harder to ... 
Responses: 2
What are the best methods for testing the efficacy of novel neuroprotective therapeutics in pre-clinical models?
An important step in moving novel neuroprotective agents towards the clinic involves testing the efficacy of therapeutics in preclinical models.  Many different preclinical models are available ... 
Responses: 15
What is the relationship between LRRK2 and synuclein? And Tau?
Mutations in the gene coding for the putative kinase LRRK2 represent some of the most prevalent genetic factors yet linked to Parkinson’s disease, but how these alterations lead to PD-related ... 
Responses: 4
Is complex 1 dysfunction a primary or secondary factor in PD pathogenesis?
Mitochondrial dysfunction has been found in brain and other body tissue in Parkinson's disease patients. Additionally, many environmental agents implicated in PD, such as pesticides, function as ... 
Responses: 7
Which LRRK2 kinase substrates identified to date are most likely to be true physiological substrates? What limitations/barriers hinder identification of novel substrates?
Mutations in the gene coding for the putative kinase LRRK2 represent some of the most prevalent genetic factors yet linked to Parkinson’s disease, but how these alterations lead to PD-related ... 
Responses: 9
Is Parkinson's a prion disease?
What is your view on the evidence for a prion-like pathological process occurring in PD either as a cause or effect of the disease? ... 
Responses: 1
What are the benefits to sharing a pre-clinical research model, other than scientific collaboration?
Widespread availability of critical research tools is necessary for rapid progress in PD research. Researchers may find, however, that the process for doing so can be time-consuming. Distribution of ... 
Responses: 5
What do we know about the function of LRRK2 in cellular processes that may shed light on its role in PD pathogenesis? Is LRRK2 kinase activity key to this regulation or do other features/functions of LRRK2 contribute?
Mutations in the gene coding for the putative kinase LRRK2 represent some of the most prevalent genetic factors yet linked to Parkinson's disease, but how these alterations lead to PD-related ... 
Responses: 3
What do we know about patterns of neuropathology in PD, and how can they drive research?
It has been reported that PD presents with characteristic patterns of cellular abnormalities and pathology across brain areas and tissues in PD, beyond the classic nigro-striatal ... 
Responses: 1
What are the best tools for detecting and isolating LRRK2 protein?
Mutations in the gene coding for the putative kinase LRRK2 represent some of the most prevalent genetic factors yet linked to Parkinson’s disease, but tools for studying LRRK2 are limited. In ... 
Responses: 4