Related Contributions

Phosphorylation of a-synuclein at S87: Commentary on Paleologou et al. (2010)
POWs: Papers of the Week
Ayse Ulusoy, Lund, et al.
16 Mar 2010
The majority of a-synuclein within Lewy bodies (LB) in PD brains and related synucleinopathies is phosphorylated. Phosphorylation of the serine residue at position 129 (S129) has been found in ... 
L-DOPA-induced dyskinesia (LID) can be difficult to quantify...
Which behavioral outcomes are relevant in rodent models of dyskinesia?
M. Angela Cenci, Lund
16 Mar 2010
L-DOPA-induced dyskinesia (LID) can be difficult to quantify in all species, primates and rodents alike. In their most common form, dyskinesias appear in the “on” phase of the L-DOPA ... 
Breakout Group: Research Models
MJFF 2010 Scientific Advisory Board Meeting
Kirsten Carlson, MJFF
15 Mar 2010
The primary goal of this breakout group was to prioritize the best rodent models for MJFF to generate or replicate in 2010 in order to make widely available to the research community, unhindered by ... 
Orolingual dyskinesia in relevance to behavior outcome in mice
Which behavioral outcomes are relevant in rodent models of dyskinesia?
Danqing Xiao
14 Mar 2010
I think abnormal involuntary movements involving opening and closing of mouth (orolingual dyskinesia) and limb will be most relevant behaviorial outcome for rodent dykinesia, evidenced in studies by ... 
Help me design a LRRK2 study?
LRRK2 Summit
Brian K. Fiske, MJFF
08 Mar 2010
As an outcome from our December 2009 LRRK2 Summit and various follow-up discussions, there are clearly a number of basic questions around LRRK2 function that remain unanswered (or only partially ... 
Validating PD targets: FK506 binding proteins
POWs: Papers of the Week
Mark Frasier, MJFF
22 Feb 2010
Digging through the POWs, I found this interesting paper from Veerle Baekelandt's group describing the role of FK506 binding proteins (FKBPs) in alpha-synuclein accumulation and alpha-synuclein ... 
Responses: 1
Anti-depressants and hippocampal cell genesis in PD
MEMBERS' OPEN FORUM: for rapid-fire posting of your questions and comments.
Dennis Steindler, UFL
02 Mar 2010
A recently published study by Suzuki et al. (Feburary 2010) reports a loss of hippocampal cell proliferation in the adult rat following midbrain 6-OHDA lesions.  Furthermore, the authors ... 
For pre-clinical PD models why not look for neuro-protection in pre-clinical pre-motor PD brain regions?
What are the best methods for testing the efficacy of novel neuroprotective therapeutics in pre-clinical models?
Veronica Miller, Wadsworth
24 Feb 2010
There are an abundence of emerging pathological and imaging studies from patients with Lewy Body diseases which strongly suggest that non-dopaminergic neurons are dysfunctional at early ... 
LRRK1-LRRK2: safe or toxic twins?
Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.
Elisa Greggio, UNIPD
16 Feb 2010
A paper recently published in Mechanisms of Ageing and Development proposes a functional and genetic association between LRRK2 and its close homologue LRRK1. PD-associated LRRK1 mutations have not ... 
ESC v. iPSC: The difference is in efficiency
Can induced pluripotent stem cells be used to generate useful Parkinson's disease cell models?
Holli Kawadler, MJFF
18 Feb 2010
There are still a number of questions to consider when looking at using iPS in both regenerative medicine and disease modeling, as outlined previously. How similar are ES and iPS cells, can we ...