Discussion

Related Research Questions

Open Forum: for rapid-fire posting of your questions and comments.
Not sure where to post your ideas? This is the place! ... 
Responses: 8
iPSC patents headed for a showdown?
A recent blog over at ScienceInsider (Landmark Pluripotent Patent Has Stem Cell Researchers Nervous) discusses the recent awarding of a patent to MIT researcher Rudolph Jaenisch and MGH researcher ... 
Responses: 1
A Lentiviral System for Inducible Intracerebroventricular Delivery
The delivery of synthetic peptides or secreted recombinant proteins to the CNS is often accomplished by intracerebroventricular (ICV) administration. This method is especially problematic for ... 
GDNF vs Neurturin: Is one better than the other?
Both GDNF and neurturin (NTN) have been in Phase II clinical trials for PD and NTN is currently being tested in a Phase I/II trial. Both are members of the GDNF family of ligands and have shown ... 
Responses: 2
Impact of species differences in therapeutic development
At an internal MJFF meeting today a panel of invited scientists discussed several topics, including the following: Moving from rodent to non-human primate models with potential therapeutic ... 
Is the Time Right for Gene Therapy?
A story in the New York Times today (After Setbacks, Small Successes for Gene Therapy by Gina Kolata) suggests a possible resurgence for gene therapy after a series of setbacks, including the ... 
Responses: 1
Seeking member input on new methods and protocol resources.
We are planning a way to organize methodological issues on PD Online - technical questions, problem solving, and members' views on best practices in the lab.  What kind of PD-related ... 
Stem cells as a means to deliver trophic factors
What are the strengths and limitations of using stem cells or other cell sources as trophic factor delivery devices?   ... 
What are the best methods for testing the efficacy of novel neuroprotective therapeutics in pre-clinical models?
An important step in moving novel neuroprotective agents towards the clinic involves testing the efficacy of therapeutics in preclinical models.  Many different preclinical models are available ... 
Responses: 15
What are the biological and psychosocial mechanisms of the placebo response, and how can we manage and/or tap the placebo response in PD clinical trials?
As is the case in other diseases, the current gold standard methodology for testing the efficacy of experimental Parkinson’s disease therapeutics involves the placebo-controlled study ... 
Responses: 10