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Genotype – phenotype correlations
LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease.
Avi Orr-Urtreger, Genetic Institute
29 Jul 2009
The results presented in this paper demonstrated genotype – phenotype correlations between LRRK2 vs GBA mutations and the initial presentation of PD. Recently, we also demonstrate ... 
Heterogeneous phenotypes from autosomal dominant mutations are not uncommon
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
John Q Trojanowski, UPENN
15 Jul 2009
Autosomal dominant genetic mutations that are pathogenic for neurodenegerative diseases, like those in genes that cause PD, AD, FTLD, ALS and other disorders, are powerful drivers of the disease ... 
Is there a parkin clinical subtype?
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
Holli Kawadler, The Michael J. Fox Foundation for Parkinson's Research
07 Jul 2009
Patients with parkin mutations often exhibit specific phenotypic characteristics (early-onset, slow progression, and the absence of Lewy body pathology), suggesting possible differences in pathogenic ... 
PD subtypes: First thing you do - katie....
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
Haydeh Payami, Wadsworth
03 Jul 2009
katie:  first thing i would do is apply the subtype information to clinical trials.   if we tried the right drug on the right patients, we would be more successful with drug ... 
PD clinical subtypes
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
Thomas G Beach, Sun Health
30 Jun 2009
If we use as a model those neurodegenerative diseases caused by single gene mutations, such as FTDP-17 (tau gene mutations), FTLD-TDP (progranulin gene mutations), LRRK2 mutations, APP mutations, ... 
Clinical PD subtypes: tremor-dominant and postural-instability-gait-difficulty (PIGD)
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
Joseph Jankovic, Baylor
22 Jun 2009
Together with my colleagues at Baylor we first proposed two major subtypes of PD, tremor-dominant and postural-instability-gait-difficulty (PIGD) in 1985 and this observation was confirmed when ... 
Subtypes -what would you do?
What are the potential PD subtypes, and how do they differ clinically and/or genetically?
Katie Hood, The Michael J. Fox Foundation for Parkinson's Research
18 Jun 2009
As anyone who knows me knows, this is something I'm fascinated by. ... 
Linking PD genetics to clinical subtypes
LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease.
Todd Sherer, The Michael J. Fox Foundation for Parkinson's Research
27 May 2009
This recent paper by Gan-Or et al provides interesting data linking PD genetics to specific clinical presentation characteristics.  This type of analysis provides a potential biological basis ...