As an outcome from our December 2009 LRRK2 Summit and various
follow-up discussions, there are clearly a number of basic questions around
LRRK2 function that remain unanswered (or only partially ...
A recent spate of papers on the functional
relationship of PINK1 and parkin, and their involvement in autophagic
degradation of mitochondria (mitophagy), have begun to illuminate our
understanding of ...
Recessive Parkinson's disease (PD) genes Parkin and PINK1 have been placed genetically in the same molecular pathway that is essential to maintain the integrity and function of ...
A
paper recently published in Mechanisms of
Ageing and Development proposes a functional and genetic association
between LRRK2 and its close homologue LRRK1. PD-associated LRRK1 mutations have
not ...
Mitochondrial complex I deficiency and alpha-synuclein abnormality (enhanced expression, mutation, and nitration) are two major pathological events in the brains of patients with Parkinson's disease ...
New findings published today in PNAS further support the role of PINK1 and parkin in mitochondrial quality control discussed by Dr. Chu in her post. Vives-Bauza et al. demonstrate that parkin, in a ...
Published
this week in Neuron, Lin and colleagues elegantly demonstrate that LRRK2 can
regulate the progression of neuropathology induced by mutant a-synuclein
in mice. In a heroic modeling effort ...
A recent paper, published in Cell Signaling, also provides support for a link between LRRK2 and alpha-synuclein through a common pathway. As stated eloquently by Dr. Moore, there a number of possible ...
Although already nearly a year old, a commentary from Drs. Greggio and Cookson (2009) provides a great overview of the main questions around our understanding of LRRK2 and its role in PD. The three ...
