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Related Research Questions

Open Forum: for rapid-fire posting of your questions and comments.
Not sure where to post your ideas? This is the place! ... 
Responses: 8
How can the adaptive immune system be targeted as a therapeutic approach for PD?
Neuroinflammation is proposed to be a major factor in creating a toxic environment in the PD brain. However, what is the contribution of the adaptive immune system (ie. T cell function) to PD ... 
Responses: 4
A Lentiviral System for Inducible Intracerebroventricular Delivery
The delivery of synthetic peptides or secreted recombinant proteins to the CNS is often accomplished by intracerebroventricular (ICV) administration. This method is especially problematic for ... 
Impact of species differences in therapeutic development
At an internal MJFF meeting today a panel of invited scientists discussed several topics, including the following: Moving from rodent to non-human primate models with potential therapeutic ... 
Polo Like Kinases as therapeutic targets in Parkinson’s disease and related synucleinopathies
Increasing evidence suggests that phosphorylation may play an important role in the oligomerization and fibrillogenesis (Fujiwara et al., 2002), Lewy body formation (Fujiwara et al., 2002; Anderson ... 
Responses: 1
Is the Time Right for Gene Therapy?
A story in the New York Times today (After Setbacks, Small Successes for Gene Therapy by Gina Kolata) suggests a possible resurgence for gene therapy after a series of setbacks, including the ... 
Responses: 1
Recent MJFF Awardee Meeting Discussion Topics
We recently held one of our frequent MJFF awardee meetings to hear about progress on a number of projects related to validating interesting new biological targets and research models for PD. As is ... 
Responses: 1
Seeking member input on new methods and protocol resources.
We are planning a way to organize methodological issues on PD Online - technical questions, problem solving, and members' views on best practices in the lab.  What kind of PD-related ... 
What are the best methods for testing the efficacy of novel neuroprotective therapeutics in pre-clinical models?
An important step in moving novel neuroprotective agents towards the clinic involves testing the efficacy of therapeutics in preclinical models.  Many different preclinical models are available ... 
Responses: 15
What are the biological and psychosocial mechanisms of the placebo response, and how can we manage and/or tap the placebo response in PD clinical trials?
As is the case in other diseases, the current gold standard methodology for testing the efficacy of experimental Parkinson’s disease therapeutics involves the placebo-controlled study ... 
Responses: 10