New PD models available through MJFF-Jackson Labs partnership

The Michael J. Fox Foundation is expanding its efforts through a partnership with The Jackson Laboratory to make pre-clinical models more widely available to the research community. It is essential that multiple groups have access to these powerful tools to verify published findings and use them to increase our understanding of Parkinson's disease and develop new therapeutic interventions. MJFF has prioritized the development of research tools and is covering the costs of transfer and housing of PD models at The Jackson Laboratory.

As of today, a number of models are already available for sale in Jackson Labs with MJFF support, including Chenjian Li's BAC LRRK2 mice and Darren Moore's alpha-synuclein mice.   More models are currently being shipped to Jackson Labs or are in the process of being rederived and will be available later this year.

MJFF is actively seeking additional models to make available through Jackson Labs. MJFF will cover shipping, cryopreservation, rederivation and first-year housing costs for models meeting specific criteria. Depending upon demand, success of the program and future MJFF priorities, there is the possibility of continued support.  If you are interested in sharing your PD model, please contact Kirsten Carlson at kcarlson@michaeljfox.org.

Gene

Model (click for add'l info)

 Status (as of 2/2/2010)

 Investigator

LRRK2 

BAC Wildtype

BAC R1441G

BAC G2019S

Available

Available

Under development

Chenjian Li

LRRK2

R1441C Tg

R1441C Knock in

Under development

Under development

Jie Shen
LRRK2

BAC Wildtype

BAC G2019S

Knockout

Under development

Under development

Under development

Matthew Farrer
Alpha-synuclein

ROSA-119

ROSA-A53T

ROSA-E46K

Available

Available

Available

Darren Moore /

Ted Dawson

Alpha-synuclein

PAC Wildtype

PAC A53T

PAC A30P

Under development

Under development

Under development

Robert Nussbaum
Parkin BAC Q311X Under development  X. William Yang

See all Parkinson's mouse models at The Jackson Laboratory.

4 Feb 2010 11:25 AM EST
Dr. Zhenyu Yue of Mount Sinai School of Medicine discusses two new BAC Lrrk2 mouse models, recently published in Journal of Neuroscience.  As The Michael J. Fox Foundation partially funded this ...