Research News
A Clue to Neuron Vulnerability
Published today in the Journal of Neuroscience, Dr. Carlos Paladini and colleagues get to the bottom of burst firing activity in dopaminergic neurons of the substantia nigra. Together with recent articles by Drs. Mark Bevan (Blythe, et al. 2009), Edwin Levitan (Putzier, et al. 2009) and James Surmeier (Guzman, et al. 2009), these papers move us one step closer to understanding the properties underlying dopaminergic neuron function.
Responses:
The interaction of calcium ...
Reference:
Bean BP. The action potential in mammalian central neurons. Nat Rev Neurosci. 2007;8(6):451-65.
Blythe SN, Wokosin D, Atherton JF, Bevan MD. Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons. J Neurosci. 2009;29(49):15531-41.
Deister CA, Teagarden MA, Wilson CJ, Paladini CA. An intrinsic neuronal oscillator underlies dopaminergic neuron bursting. J Neurosci. 2009;29(50):15888-97.
Guzman JN, Sánchez-Padilla J, Chan SC, Surmeier JD. Robust pacemaking in substantia nigra dopaminergic neurons. J Neurosci. 2009;29(35):11011-9.
Putzier I, Kullmann PH, Horn JP, Levitan ES. Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons. J Neurosci. 2009;29(49):15414-9.
Calcium, pacemaking and ...
Reference:
Blythe SN, Wokosin D, Atherton JF, Bevan MD. Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons. J Neurosci. 2009;29(49):15531-41.
Chan SC, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, et al. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature. 2007;447(7148):1081-6.
Deister CA, Teagarden MA, Wilson CJ, Paladini CA. An intrinsic neuronal oscillator underlies dopaminergic neuron bursting. J Neurosci. 2009;29(50):15888-97.
Guzman JN, Sánchez-Padilla J, Chan SC, Surmeier JD. Robust pacemaking in substantia nigra dopaminergic neurons. J Neurosci. 2009;29(35):11011-9.
Harnett MT, Bernier BE, Ahn KC, Morikawa H. Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. Neuron. 2009;62(6):826-38.
Morikawa H, Khodakhah K, Williams JT. Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons. J Neurosci. 2003;23(1):149-57.
Ping HX, Shepard PD. Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. Neuroreport. 1996;7(3):809-14.
Putzier I, Kullmann PH, Horn JP, Levitan ES. Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons. J Neurosci. 2009;29(49):15414-9.
Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, et al. Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009;75(2):407-14.
Wilson CJ, Callaway JC. Coupled oscillator model of the dopaminergic neuron of the substantia nigra. J Neurophysiol. 2000;83(5):3084-100.
Wolfart J, Neuhoff H, Franz O, Roeper J. Differential expression of the small-conductance, calcium-activated potassium channel SK3 is critical for pacemaker control in dopaminergic midbrain neurons. J Neurosci. 2001;21(10):3443-56.
Response to Dr. Surmeier
Reference:
Putzier I, Kullmann PH, Horn JP, Levitan ES. Cav1.3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons. J Neurosci. 2009;29(49):15414-9.
Wolfart J, Roeper J. Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons. J Neurosci. 2002;22(9):3404-13.
Koschak A, Reimer D, Huber I, Grabner M, Glossmann H, Engel J, et al. alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem. 2001;276(25):22100-6.
Xu W, Lipscombe D. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J Neurosci. 2001;21(16):5944-51.
Safa P, Boulter J, Hales TG. Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells. J Biol Chem. 2001;276(42):38727-37.
Puopolo M, Raviola E, Bean BP. Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons. J Neurosci. 2007;27(3):645-56.
Guzman JN, Sánchez-Padilla J, Chan SC, Surmeier JD. Robust pacemaking in substantia nigra dopaminergic neurons. J Neurosci. 2009;29(35):11011-9.
Mercuri NB, Bonci A, Calabresi P, Stratta F, Stefani A, Bernardi G. Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones. Br J Pharmacol. 1994;113(3):831-8.
Deister CA, Teagarden MA, Wilson CJ, Paladini CA. An intrinsic neuronal oscillator underlies dopaminergic neuron bursting. J Neurosci. 2009;29(50):15888-97.
Blythe SN, Wokosin D, Atherton JF, Bevan MD. Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons. J Neurosci. 2009;29(49):15531-41.
Dihydropyridines, ...
Reference:
Bean BP. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci USA. 1984;81(20):6388-92.
Becker C, Jick SS, Meier CR. Use of antihypertensives and the risk of Parkinson disease. Neurology. 2008;70(16 Pt 2):1438-44.
