Zhenyu Yue, Ph. D.

Job title:
Associate Professor
Organization:
Mount Sinai School of Medicine
Technology:
biochemistry
cell biology; molecular biology; animal models
PD Guide Terms:
Etiology
Therapeutic Development
Contributions:
Published Contributions:
Is LRRK2 kinase activity the real culprit?
What do we know about the function of LRRK2 in cellular processes that may shed light on its role in PD pathogenesis? Is LRRK2 kinase activity key to this regulation or do other features/functions of LRRK2 contribute?
29 Jul 2009 06:44 PM EST
Although LRRK2 is considered one of the most promising drug targets for PD, currently we know very little about its biological function and structure, or how LRRK2 mutations affect its functions that ... 
Characterization of new BAC LRRK2 WT and G2019S mouse models - Q&A with Dr. Zhenyu Yue
New PD models available through MJFF-Jackson Labs partnership
4 Feb 2010 11:25 AM EST
Dr. Zhenyu Yue of Mount Sinai School of Medicine discusses two new BAC Lrrk2 mouse models, recently published in Journal of Neuroscience.  As The Michael J. Fox Foundation partially funded this ... 
Characterize new LRRK2 antibodies in FLAG tagged LRRK2 BAC transgenic mice
LRRK2 Antibodies
3 Jun 2010 04:44 PM EST
Brain treatment and Immunohistochemistry: FLAG-LRRK2-WT transgenic mouse and littermate non-transgenic control mouse were anesthetized and perfused with 30ml cold PBS (pH 7.4) and 30ml 4% ...