Girija Muralidhar, Ph.D

Job title:
Director of Vaccines Program
Organization:
Bio:

GIRIJA MURALIDHAR, Ph.D
11536, Wind Crest Lane Apt 300

San Diego, CA 92128

 

 

                                                                                                            Phone: 858-521-9134

 girijamg@yahoo.com                                                                           Cell:    858-869-4919                                                                                                 

Citizenship: USA

 

SUMMARY

 

Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant.  Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.

 

PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS

 

At present      Director, Vaccine Program, Virogenics, San Diego, CA

Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors

 

2006-2008    Section Head, Immunology, Thrombosis Research Institute, Bangalore, India

Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry

 

2003-2007    Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA

Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV as

        a vaccine for AIDS.

Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.

 

2000-2002          Co-Chair of Preclinical Studies, GenStar Therapeutics,  San Diego, CA

Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member

 

1997-2000          Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,

San Diego, CA

Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues

 

1992-1996           Assistant Research Scientist, University of California, San Diego, Cancer Center,   La Jolla, CA

Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students

 

1989-1991      Postgraduate Research Biochemist, University of California, San Diego,

Cancer Center, La Jolla, CA

Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.

 

 

EDUCATIONAL RECORD:

 

1988-1989    Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford    

                        University, Stanford, CA

Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.

 

1983-1987          Ph.D., Department of Physiological Chemistry, Ohio State University,

                      Columbus, OH

Established the role of altered transfer RNAs in chemical carcinogenesis.

 

1982-1983     Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India

Identified biochemical markers for childhood leukemias.

 

1979-1981             Graduate Student, M.Sc. in Biochemistry, University of Baroda, India

Studied the impact of nutritional deficiencies on bone development during pregnancy.

 

1976-1979             B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India

 

 

HONORS AND AWARDS:

 

2005                                 Equipment grant from NIH

2004                                 R-21 grant from NIH

1998                                 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.

1995-present                    Managing Editor, Advances in Biosciences

1994-2000                                              R-29 First Award from NCI

1994                                 Junior Investigator Award, UCAIDS Task Force

1993-present                    Member, The American Association of Immunologists (AAI)

1993-present                    Reviewer for Journal of Immunology, Cellular Immunology and Blood

1992                                 Recipient of AAI Travel Award to attend the 8th International Congress     

 

PUBLICATIONS:

 

Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and Sriramarao, P.  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006

Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L.  Development of an adenoviral-based vaccine for HIV/AIDS.  CellSciences, 2005

 

Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system.  Current HIV Research, 3: 157-181, 2005

 

Muralidhar, G.  Role of gag protein in Murine AIDS.  Proceedings of 10th International Congress of Immunology, 1281-1287, 1998. 

 

Andrews, C., Swain, S. L., and Muralidhar, G.  CD4 T cell anergy in MAIDS.  Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells.  J Immunol. 159: 2132-2138, 1997.

 

Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L.  TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.

157: 625-635, 1996.

 

Koch, S., Muralidhar, G. and Swain, S.L.  Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.  J. Immunol. 152:5548-5556, 1994.

 

Muralidhar, G., Koch, S. and Swain, S.L.  CD4 T cell subsets and superantigen in MAIDS.  In:  Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.

 

Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression.  I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC.  J. Immunol. 149:3574-3579, 1992.

 

Muralidhar, G., Koch, S., Haas, M. and Swain, S.L.  CD4 T cells in murine acquired immuno-deficiency syndrome:  Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.

 

Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley.   Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains.  Infection and Immunity, 2089-2096, 1991.

 

Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells.  Cancer Res. 49:7110-7114, 1989.  

 

Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W.   Identifying inhibitors of queuine modification of tRNA in cultured cells.  Analytical Biochem. 171:346-351, 1988.

 

Muralidhar, G., and Trewyn, R.W.   Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.

 

Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G.   Hematopoiesis and the inosine modification in transfer RNA.  Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.

 

Manuscripts in preparation/submitted

 

Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cell-based vaccine for atherosclerosis.

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cells and cytokines in CAD patients:  Implications for Vaccine development.

 

 

References

Will be provided upon request

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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GIRIJA MURALIDHAR, Ph.D
11536, Wind Crest Lane Apt 300

San Diego, CA 92128

 

 

                                                                                                            Phone: 858-521-9134

 girijamg@yahoo.com                                                                           Cell:    858-869-4919                                                                                                 

Citizenship: USA

 

SUMMARY

 

Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant.  Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.

 

PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS

 

At present      Director, Vaccine Program, Virogenics, San Diego, CA

Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors

 

2006-2008    Section Head, Immunology, Thrombosis Research Institute, Bangalore, India

Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry

 

2003-2007    Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA

Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV as

        a vaccine for AIDS.

Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.

 

2000-2002          Co-Chair of Preclinical Studies, GenStar Therapeutics,  San Diego, CA

Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member

 

1997-2000          Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,

San Diego, CA

Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues

 

1992-1996           Assistant Research Scientist, University of California, San Diego, Cancer Center,   La Jolla, CA

Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students

 

1989-1991      Postgraduate Research Biochemist, University of California, San Diego,

Cancer Center, La Jolla, CA

Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.

 

 

EDUCATIONAL RECORD:

 

1988-1989    Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford    

                        University, Stanford, CA

Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.

 

1983-1987          Ph.D., Department of Physiological Chemistry, Ohio State University,

                      Columbus, OH

Established the role of altered transfer RNAs in chemical carcinogenesis.

 

1982-1983     Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India

Identified biochemical markers for childhood leukemias.

 

1979-1981             Graduate Student, M.Sc. in Biochemistry, University of Baroda, India

Studied the impact of nutritional deficiencies on bone development during pregnancy.

 

1976-1979             B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India

 

 

HONORS AND AWARDS:

 

2005                                 Equipment grant from NIH

2004                                 R-21 grant from NIH

1998                                 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.

1995-present                    Managing Editor, Advances in Biosciences

1994-2000                                              R-29 First Award from NCI

1994                                 Junior Investigator Award, UCAIDS Task Force

1993-present                    Member, The American Association of Immunologists (AAI)

1993-present                    Reviewer for Journal of Immunology, Cellular Immunology and Blood

1992                                 Recipient of AAI Travel Award to attend the 8th International Congress     

 

PUBLICATIONS:

 

Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and Sriramarao, P.  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006

Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L.  Development of an adenoviral-based vaccine for HIV/AIDS.  CellSciences, 2005

 

Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system.  Current HIV Research, 3: 157-181, 2005

 

Muralidhar, G.  Role of gag protein in Murine AIDS.  Proceedings of 10th International Congress of Immunology, 1281-1287, 1998. 

 

Andrews, C., Swain, S. L., and Muralidhar, G.  CD4 T cell anergy in MAIDS.  Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells.  J Immunol. 159: 2132-2138, 1997.

 

Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L.  TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.

157: 625-635, 1996.

 

Koch, S., Muralidhar, G. and Swain, S.L.  Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.  J. Immunol. 152:5548-5556, 1994.

 

Muralidhar, G., Koch, S. and Swain, S.L.  CD4 T cell subsets and superantigen in MAIDS.  In:  Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.

 

Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression.  I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC.  J. Immunol. 149:3574-3579, 1992.

 

Muralidhar, G., Koch, S., Haas, M. and Swain, S.L.  CD4 T cells in murine acquired immuno-deficiency syndrome:  Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.

 

Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley.   Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains.  Infection and Immunity, 2089-2096, 1991.

 

Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells.  Cancer Res. 49:7110-7114, 1989.  

 

Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W.   Identifying inhibitors of queuine modification of tRNA in cultured cells.  Analytical Biochem. 171:346-351, 1988.

 

Muralidhar, G., and Trewyn, R.W.   Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.

 

Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G.   Hematopoiesis and the inosine modification in transfer RNA.  Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.

 

Manuscripts in preparation/submitted

 

Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cell-based vaccine for atherosclerosis.

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cells and cytokines in CAD patients:  Implications for Vaccine development.

 

 

References

Will be provided upon request

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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GIRIJA MURALIDHAR, Ph.D
11536, Wind Crest Lane Apt 300

San Diego, CA 92128

 

 

                                                                                                            Phone: 858-521-9134

 girijamg@yahoo.com                                                                           Cell:    858-869-4919                                                                                                 

Citizenship: USA

 

SUMMARY

 

Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant.  Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.

 

PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS

 

At present      Director, Vaccine Program, Virogenics, San Diego, CA

Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors

 

2006-2008    Section Head, Immunology, Thrombosis Research Institute, Bangalore, India

Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry

 

2003-2007    Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA

Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV as

        a vaccine for AIDS.

Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.

 

2000-2002          Co-Chair of Preclinical Studies, GenStar Therapeutics,  San Diego, CA

Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member

 

1997-2000          Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,

San Diego, CA

Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues

 

1992-1996           Assistant Research Scientist, University of California, San Diego, Cancer Center,   La Jolla, CA

Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students

 

1989-1991      Postgraduate Research Biochemist, University of California, San Diego,

Cancer Center, La Jolla, CA

Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.

 

 

EDUCATIONAL RECORD:

 

1988-1989    Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford    

                        University, Stanford, CA

Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.

 

1983-1987          Ph.D., Department of Physiological Chemistry, Ohio State University,

                      Columbus, OH

Established the role of altered transfer RNAs in chemical carcinogenesis.

 

1982-1983     Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India

Identified biochemical markers for childhood leukemias.

 

1979-1981             Graduate Student, M.Sc. in Biochemistry, University of Baroda, India

Studied the impact of nutritional deficiencies on bone development during pregnancy.

 

1976-1979             B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India

 

 

HONORS AND AWARDS:

 

2005                                 Equipment grant from NIH

2004                                 R-21 grant from NIH

1998                                 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.

1995-present                    Managing Editor, Advances in Biosciences

1994-2000                                              R-29 First Award from NCI

1994                                 Junior Investigator Award, UCAIDS Task Force

1993-present                    Member, The American Association of Immunologists (AAI)

1993-present                    Reviewer for Journal of Immunology, Cellular Immunology and Blood

1992                                 Recipient of AAI Travel Award to attend the 8th International Congress     

 

PUBLICATIONS:

 

Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and Sriramarao, P.  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006

Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L.  Development of an adenoviral-based vaccine for HIV/AIDS.  CellSciences, 2005

 

Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system.  Current HIV Research, 3: 157-181, 2005

 

Muralidhar, G.  Role of gag protein in Murine AIDS.  Proceedings of 10th International Congress of Immunology, 1281-1287, 1998. 

 

Andrews, C., Swain, S. L., and Muralidhar, G.  CD4 T cell anergy in MAIDS.  Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells.  J Immunol. 159: 2132-2138, 1997.

 

Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L.  TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.

157: 625-635, 1996.

 

Koch, S., Muralidhar, G. and Swain, S.L.  Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.  J. Immunol. 152:5548-5556, 1994.

 

Muralidhar, G., Koch, S. and Swain, S.L.  CD4 T cell subsets and superantigen in MAIDS.  In:  Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.

 

Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression.  I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC.  J. Immunol. 149:3574-3579, 1992.

 

Muralidhar, G., Koch, S., Haas, M. and Swain, S.L.  CD4 T cells in murine acquired immuno-deficiency syndrome:  Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.

 

Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley.   Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains.  Infection and Immunity, 2089-2096, 1991.

 

Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells.  Cancer Res. 49:7110-7114, 1989.  

 

Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W.   Identifying inhibitors of queuine modification of tRNA in cultured cells.  Analytical Biochem. 171:346-351, 1988.

 

Muralidhar, G., and Trewyn, R.W.   Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.

 

Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G.   Hematopoiesis and the inosine modification in transfer RNA.  Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.

 

Manuscripts in preparation/submitted

 

Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cell-based vaccine for atherosclerosis.

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cells and cytokines in CAD patients:  Implications for Vaccine development.

 

 

References

Will be provided upon request

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

GIRIJA MURALIDHAR, Ph.D
11536, Wind Crest Lane Apt 300

 

San Diego, CA 92128

 

 

                                                                                                            Phone: 858-521-9134

 girijamg@yahoo.com                                                                           Cell:    858-869-4919                                                                                                 

Citizenship: USA

 

SUMMARY

 

Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant.  Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.

 

PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS

 

At present      Director, Vaccine Program, Virogenics, San Diego, CA

Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors

 

2006-2008    Section Head, Immunology, Thrombosis Research Institute, Bangalore, India

Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry

 

2003-2007    Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA

Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV as

        a vaccine for AIDS.

Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.

 

2000-2002          Co-Chair of Preclinical Studies, GenStar Therapeutics,  San Diego, CA

Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member

 

1997-2000          Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,

San Diego, CA

Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues

 

1992-1996           Assistant Research Scientist, University of California, San Diego, Cancer Center,   La Jolla, CA

Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students

 

1989-1991      Postgraduate Research Biochemist, University of California, San Diego,

Cancer Center, La Jolla, CA

Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.

 

 

EDUCATIONAL RECORD:

 

1988-1989    Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford    

                        University, Stanford, CA

Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.

 

1983-1987          Ph.D., Department of Physiological Chemistry, Ohio State University,

                      Columbus, OH

Established the role of altered transfer RNAs in chemical carcinogenesis.

 

1982-1983     Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India

Identified biochemical markers for childhood leukemias.

 

1979-1981             Graduate Student, M.Sc. in Biochemistry, University of Baroda, India

Studied the impact of nutritional deficiencies on bone development during pregnancy.

 

1976-1979             B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India

 

 

HONORS AND AWARDS:

 

2005                                 Equipment grant from NIH

2004                                 R-21 grant from NIH

1998                                 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.

1995-present                    Managing Editor, Advances in Biosciences

1994-2000                                              R-29 First Award from NCI

1994                                 Junior Investigator Award, UCAIDS Task Force

1993-present                    Member, The American Association of Immunologists (AAI)

1993-present                    Reviewer for Journal of Immunology, Cellular Immunology and Blood

1992                                 Recipient of AAI Travel Award to attend the 8th International Congress     

 

PUBLICATIONS:

 

Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and Sriramarao, P.  Sustained exposure to nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006

Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L.  Development of an adenoviral-based vaccine for HIV/AIDS.  CellSciences, 2005

 

Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system.  Current HIV Research, 3: 157-181, 2005

 

Muralidhar, G.  Role of gag protein in Murine AIDS.  Proceedings of 10th International Congress of Immunology, 1281-1287, 1998. 

 

Andrews, C., Swain, S. L., and Muralidhar, G.  CD4 T cell anergy in MAIDS.  Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells.  J Immunol. 159: 2132-2138, 1997.

 

Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L.  TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.

157: 625-635, 1996.

 

Koch, S., Muralidhar, G. and Swain, S.L.  Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease.  J. Immunol. 152:5548-5556, 1994.

 

Muralidhar, G., Koch, S. and Swain, S.L.  CD4 T cell subsets and superantigen in MAIDS.  In:  Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.

 

Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression.  I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC.  J. Immunol. 149:3574-3579, 1992.

 

Muralidhar, G., Koch, S., Haas, M. and Swain, S.L.  CD4 T cells in murine acquired immuno-deficiency syndrome:  Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.

 

Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley.   Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains.  Infection and Immunity, 2089-2096, 1991.

 

Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells.  Cancer Res. 49:7110-7114, 1989.  

 

Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W.   Identifying inhibitors of queuine modification of tRNA in cultured cells.  Analytical Biochem. 171:346-351, 1988.

 

Muralidhar, G., and Trewyn, R.W.   Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.

 

Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G.   Hematopoiesis and the inosine modification in transfer RNA.  Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.

 

Manuscripts in preparation/submitted

 

Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cell-based vaccine for atherosclerosis.

 

Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V.  Dendritic cells and cytokines in CAD patients:  Implications for Vaccine development.

 

 

References

Will be provided upon request

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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