Girija Muralidhar, Ph.D
GIRIJA MURALIDHAR,
Ph.D
11536, Wind Crest Lane Apt
300
San Diego, CA 92128
Phone: 858-521-9134
girijamg@yahoo.com Cell: 858-869-4919
Citizenship: USA
SUMMARY
Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry. 15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant. Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.
PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS
At present Director, Vaccine Program, Virogenics, San Diego, CA
Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors
2006-2008 Section Head, Immunology, Thrombosis Research Institute, Bangalore, India
Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry
2003-2007 Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA
Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV asa vaccine for AIDS.
Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.
2000-2002 Co-Chair of Preclinical Studies, GenStar Therapeutics, San Diego, CA
Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member
1997-2000 Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,
San Diego, CA
Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues
1992-1996 Assistant Research Scientist, University of California, San Diego, Cancer Center, La Jolla, CA
Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students
1989-1991 Postgraduate Research Biochemist, University of California, San Diego,
Cancer Center, La Jolla, CA
Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.
EDUCATIONAL RECORD:
1988-1989 Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford
University, Stanford, CA
Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.
1983-1987 Ph.D., Department of Physiological Chemistry, Ohio State University,
Columbus, OH
Established the role of altered transfer RNAs in chemical carcinogenesis.
1982-1983 Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India
Identified biochemical markers for childhood leukemias.
1979-1981 Graduate Student, M.Sc. in Biochemistry, University of Baroda, India
Studied the impact of nutritional deficiencies on bone development during pregnancy.
1976-1979 B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India
HONORS AND AWARDS:
2005 Equipment grant from NIH
2004 R-21 grant from NIH
1998 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.
1995-present Managing Editor, Advances in Biosciences
1994-2000 R-29 First Award from NCI
1994 Junior Investigator Award, UCAIDS Task Force
1993-present Member, The American Association of Immunologists (AAI)
1993-present Reviewer for Journal of Immunology, Cellular Immunology and Blood
1992 Recipient of AAI Travel Award to attend the 8th International Congress
PUBLICATIONS:
Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and
Sriramarao, P. Sustained exposure to
nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006
Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L. Development of an adenoviral-based vaccine for HIV/AIDS. CellSciences, 2005
Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system. Current HIV Research, 3: 157-181, 2005
Muralidhar, G. Role of gag protein in Murine AIDS. Proceedings of 10th International Congress of Immunology, 1281-1287, 1998.
Andrews, C., Swain, S. L., and Muralidhar, G. CD4 T cell anergy in MAIDS. Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells. J Immunol. 159: 2132-2138, 1997.
Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.
157: 625-635, 1996.
Koch, S., Muralidhar, G. and Swain, S.L. Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. J. Immunol. 152:5548-5556, 1994.
Muralidhar, G., Koch, S. and Swain, S.L. CD4 T cell subsets and superantigen in MAIDS. In: Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.
Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression. I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC. J. Immunol. 149:3574-3579, 1992.
Muralidhar, G., Koch, S., Haas, M. and Swain, S.L. CD4 T cells in murine acquired immuno-deficiency syndrome: Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.
Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley. Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains. Infection and Immunity, 2089-2096, 1991.
Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells. Cancer Res. 49:7110-7114, 1989.
Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W. Identifying inhibitors of queuine modification of tRNA in cultured cells. Analytical Biochem. 171:346-351, 1988.
Muralidhar, G., and Trewyn, R.W. Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.
Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G. Hematopoiesis and the inosine modification in transfer RNA. Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.
Manuscripts in preparation/submitted
Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cell-based vaccine for atherosclerosis.
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cells and cytokines in CAD patients: Implications for Vaccine development.
References
Will be provided upon request
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GIRIJA MURALIDHAR,
Ph.D
11536, Wind Crest Lane Apt
300
San Diego, CA 92128
Phone: 858-521-9134
girijamg@yahoo.com Cell: 858-869-4919
Citizenship: USA
SUMMARY
Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry. 15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant. Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.
PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS
At present Director, Vaccine Program, Virogenics, San Diego, CA
Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors
2006-2008 Section Head, Immunology, Thrombosis Research Institute, Bangalore, India
Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry
2003-2007 Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA
Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV asa vaccine for AIDS.
Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.
2000-2002 Co-Chair of Preclinical Studies, GenStar Therapeutics, San Diego, CA
Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member
1997-2000 Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,
San Diego, CA
Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues
1992-1996 Assistant Research Scientist, University of California, San Diego, Cancer Center, La Jolla, CA
Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students
1989-1991 Postgraduate Research Biochemist, University of California, San Diego,
Cancer Center, La Jolla, CA
Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.
EDUCATIONAL RECORD:
1988-1989 Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford
University, Stanford, CA
Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.
1983-1987 Ph.D., Department of Physiological Chemistry, Ohio State University,
Columbus, OH
Established the role of altered transfer RNAs in chemical carcinogenesis.
1982-1983 Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India
Identified biochemical markers for childhood leukemias.
1979-1981 Graduate Student, M.Sc. in Biochemistry, University of Baroda, India
Studied the impact of nutritional deficiencies on bone development during pregnancy.
1976-1979 B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India
HONORS AND AWARDS:
2005 Equipment grant from NIH
2004 R-21 grant from NIH
1998 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.
1995-present Managing Editor, Advances in Biosciences
1994-2000 R-29 First Award from NCI
1994 Junior Investigator Award, UCAIDS Task Force
1993-present Member, The American Association of Immunologists (AAI)
1993-present Reviewer for Journal of Immunology, Cellular Immunology and Blood
1992 Recipient of AAI Travel Award to attend the 8th International Congress
PUBLICATIONS:
Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and
Sriramarao, P. Sustained exposure to
nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006
Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L. Development of an adenoviral-based vaccine for HIV/AIDS. CellSciences, 2005
Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system. Current HIV Research, 3: 157-181, 2005
Muralidhar, G. Role of gag protein in Murine AIDS. Proceedings of 10th International Congress of Immunology, 1281-1287, 1998.
Andrews, C., Swain, S. L., and Muralidhar, G. CD4 T cell anergy in MAIDS. Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells. J Immunol. 159: 2132-2138, 1997.
Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.
157: 625-635, 1996.
Koch, S., Muralidhar, G. and Swain, S.L. Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. J. Immunol. 152:5548-5556, 1994.
Muralidhar, G., Koch, S. and Swain, S.L. CD4 T cell subsets and superantigen in MAIDS. In: Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.
Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression. I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC. J. Immunol. 149:3574-3579, 1992.
Muralidhar, G., Koch, S., Haas, M. and Swain, S.L. CD4 T cells in murine acquired immuno-deficiency syndrome: Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.
Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley. Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains. Infection and Immunity, 2089-2096, 1991.
Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells. Cancer Res. 49:7110-7114, 1989.
Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W. Identifying inhibitors of queuine modification of tRNA in cultured cells. Analytical Biochem. 171:346-351, 1988.
Muralidhar, G., and Trewyn, R.W. Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.
Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G. Hematopoiesis and the inosine modification in transfer RNA. Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.
Manuscripts in preparation/submitted
Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cell-based vaccine for atherosclerosis.
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cells and cytokines in CAD patients: Implications for Vaccine development.
References
Will be provided upon request
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GIRIJA MURALIDHAR,
Ph.D
11536, Wind Crest Lane Apt
300
San Diego, CA 92128
Phone: 858-521-9134
girijamg@yahoo.com Cell: 858-869-4919
Citizenship: USA
SUMMARY
Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry. 15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant. Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.
PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS
At present Director, Vaccine Program, Virogenics, San Diego, CA
Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors
2006-2008 Section Head, Immunology, Thrombosis Research Institute, Bangalore, India
Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry
2003-2007 Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA
Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV asa vaccine for AIDS.
Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.
2000-2002 Co-Chair of Preclinical Studies, GenStar Therapeutics, San Diego, CA
Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member
1997-2000 Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,
San Diego, CA
Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues
1992-1996 Assistant Research Scientist, University of California, San Diego, Cancer Center, La Jolla, CA
Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students
1989-1991 Postgraduate Research Biochemist, University of California, San Diego,
Cancer Center, La Jolla, CA
Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.
EDUCATIONAL RECORD:
1988-1989 Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford
University, Stanford, CA
Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.
1983-1987 Ph.D., Department of Physiological Chemistry, Ohio State University,
Columbus, OH
Established the role of altered transfer RNAs in chemical carcinogenesis.
1982-1983 Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India
Identified biochemical markers for childhood leukemias.
1979-1981 Graduate Student, M.Sc. in Biochemistry, University of Baroda, India
Studied the impact of nutritional deficiencies on bone development during pregnancy.
1976-1979 B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India
HONORS AND AWARDS:
2005 Equipment grant from NIH
2004 R-21 grant from NIH
1998 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.
1995-present Managing Editor, Advances in Biosciences
1994-2000 R-29 First Award from NCI
1994 Junior Investigator Award, UCAIDS Task Force
1993-present Member, The American Association of Immunologists (AAI)
1993-present Reviewer for Journal of Immunology, Cellular Immunology and Blood
1992 Recipient of AAI Travel Award to attend the 8th International Congress
PUBLICATIONS:
Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and
Sriramarao, P. Sustained exposure to
nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006
Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L. Development of an adenoviral-based vaccine for HIV/AIDS. CellSciences, 2005
Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system. Current HIV Research, 3: 157-181, 2005
Muralidhar, G. Role of gag protein in Murine AIDS. Proceedings of 10th International Congress of Immunology, 1281-1287, 1998.
Andrews, C., Swain, S. L., and Muralidhar, G. CD4 T cell anergy in MAIDS. Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells. J Immunol. 159: 2132-2138, 1997.
Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.
157: 625-635, 1996.
Koch, S., Muralidhar, G. and Swain, S.L. Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. J. Immunol. 152:5548-5556, 1994.
Muralidhar, G., Koch, S. and Swain, S.L. CD4 T cell subsets and superantigen in MAIDS. In: Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.
Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression. I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC. J. Immunol. 149:3574-3579, 1992.
Muralidhar, G., Koch, S., Haas, M. and Swain, S.L. CD4 T cells in murine acquired immuno-deficiency syndrome: Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.
Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley. Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains. Infection and Immunity, 2089-2096, 1991.
Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells. Cancer Res. 49:7110-7114, 1989.
Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W. Identifying inhibitors of queuine modification of tRNA in cultured cells. Analytical Biochem. 171:346-351, 1988.
Muralidhar, G., and Trewyn, R.W. Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.
Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G. Hematopoiesis and the inosine modification in transfer RNA. Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.
Manuscripts in preparation/submitted
Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cell-based vaccine for atherosclerosis.
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cells and cytokines in CAD patients: Implications for Vaccine development.
References
Will be provided upon request
GIRIJA MURALIDHAR,
Ph.D
11536, Wind Crest Lane Apt
300
San Diego, CA 92128
Phone: 858-521-9134
girijamg@yahoo.com Cell: 858-869-4919
Citizenship: USA
SUMMARY
Ph.D scientist with expertise in Virology, Immunology, Vaccines and Biochemistry. 15 years of successful grant writing experience. Secured a variety of NIH grants, R29, R21, R41 and Equipment Grant. Participated in Program projects, Center for Excellence and Cancer Center grants and various non-NIH grants: UCAIDS Task Force, Tobacco and Arthritis foundation Excellent written and oral communication, supervisory and administrative skills.
PROFESSIONAL EXPERIENCE AND ACCOMPLISHMENTS
At present Director, Vaccine Program, Virogenics, San Diego, CA
Grant Writer: Secured NIH funding (SBIR, $250,000) for the vaccine program to evaluate novel adjuvants with DNA vaccines for HIV Developed novel immuno-modulatory agents and adjuvants from adenoviral vectors
2006-2008 Section Head, Immunology, Thrombosis Research Institute, Bangalore, India
Contributed to “Center for Excellency” grant Collaborated and coordinated with research teams in Budapest and London to develop a vaccine for atherosclerosis. Evaluated dendritic cells as antigen carriers: designed a DC-DNA vaccine to prevent atherosclerosis Conducted training sessions in Immunological techniques and Flow cytometry
2003-2007 Director of Flow Cytometry Core Facility and Assistant Professor, La Jolla Institute for Molecular Medicine, San Diego, CA
Awarded an Equipment grant ($175,000) from the NIH Purchased a Dual-laser, 12-color flow cytometer (LSRII) for the facility Established a Flow cytometry core facility at LJIMM for the use of 30 researchers Secured funding from NIH (R21, $300,000) to evaluate PEGylated AdHIV asa vaccine for AIDS.
Demonstrated the utility of PEGylated AdHIV as a better vaccine (induced anti-HIV responses but not anti-Ad immune responses) in preclinical studies Utilized adenoviral proteins as immune modulators and therapeutic agents for the treatment of allergic asthma.
2000-2002 Co-Chair of Preclinical Studies, GenStar Therapeutics, San Diego, CA
Generated and evaluated the efficacy of Adenoviral-based HIV vaccine. Demonstrated that AdHIV induced long lasting immunological memory to HIV as well as Ad epitopes Collaborated with a team developing Ad-based tumor specific vaccines and lentiviral-based vaccine for HIV Grant writer: Helped GenStar procure grants from NIH (R-21 and SBIR, $500,000) for the Vaccine Program. Developed biochemical assays for VEGF-2, HIV gag and pol and tumor markers. Radiation Safety Officer and IACUC member
1997-2000 Assistant Professor, Immunology Program, Sidney Kimmel Cancer Center,
San Diego, CA
Evaluated immunological and biochemical basis of T cell anergy in Murine AIDS. Developed strategies to restore CD4 T cell function in Murine AIDS after anti-retroviral therapy. Established collaborations with Glaxo Wellcome, Research Triangle Park, NC, to test anti-viral drugs in vitro Managed Flow Cytometry Core facility and trained colleagues
1992-1996 Assistant Research Scientist, University of California, San Diego, Cancer Center, La Jolla, CA
Evaluated CD4 T cell anergy in Murine AIDS. Secured funding (R29, $350,000) from the NIH to conduct research on CD4 T cell anergy in MAIDS. Studied V gene specific regulation of immunoglobulin gene expression Trained minority and women students as Faculty Mentor Trained several undergraduate and graduate students Designed and conducted a course in Flow Cytometry for graduate students
1989-1991 Postgraduate Research Biochemist, University of California, San Diego,
Cancer Center, La Jolla, CA
Developed RT-PCR techniques for cytokine RNA quantitation. Evaluated superantigen-mediated T cell activation and anergy.
EDUCATIONAL RECORD:
1988-1989 Postdoctoral Fellow, Department of Microbiology & Immunology, Stanford
University, Stanford, CA
Determined the pathogenecity of Digalactoside binding E.coli strains. Identified roundworm (Ascaris lumbricoides) antigens responsible for protective immunity to infection in endemic areas.
1983-1987 Ph.D., Department of Physiological Chemistry, Ohio State University,
Columbus, OH
Established the role of altered transfer RNAs in chemical carcinogenesis.
1982-1983 Junior Research Fellow, Kidwai Memorial Institute of Oncology, Bangalore, India
Identified biochemical markers for childhood leukemias.
1979-1981 Graduate Student, M.Sc. in Biochemistry, University of Baroda, India
Studied the impact of nutritional deficiencies on bone development during pregnancy.
1976-1979 B.Sc., Majored in Biology and Chemistry, V.R. College, Nellore, India
HONORS AND AWARDS:
2005 Equipment grant from NIH
2004 R-21 grant from NIH
1998 Recipient of AAI Travel Award to attend the 10th International Congress of Immunology, New Delhi, India.
1995-present Managing Editor, Advances in Biosciences
1994-2000 R-29 First Award from NCI
1994 Junior Investigator Award, UCAIDS Task Force
1993-present Member, The American Association of Immunologists (AAI)
1993-present Reviewer for Journal of Immunology, Cellular Immunology and Blood
1992 Recipient of AAI Travel Award to attend the 8th International Congress
PUBLICATIONS:
Pandit, T.S., Sikora, L., Muralidhar, G., Rao, S.P., and
Sriramarao, P. Sustained exposure to
nicotine leads to extramedullary hematopoiesis in the spleen.
Stem Cells. 24: 2373-2381, 2006
Muralidhar, G., Navaratnam, M., Englund, N., Hariharan, M.J and Sauter, S.L. Development of an adenoviral-based vaccine for HIV/AIDS. CellSciences, 2005
Sauter, S., Rahman, A and Muralidhar, G. Non-replicating viral vector-based AIDS vaccines: Interplay between viral vectors and the immune system. Current HIV Research, 3: 157-181, 2005
Muralidhar, G. Role of gag protein in Murine AIDS. Proceedings of 10th International Congress of Immunology, 1281-1287, 1998.
Andrews, C., Swain, S. L., and Muralidhar, G. CD4 T cell anergy in MAIDS. Costimulation via CD28 and the addition of IL-12 are not sufficient to rescue anergic CD4 T cells. J Immunol. 159: 2132-2138, 1997.
Muralidhar, G., Koch, S., Broome, H.E., and Swain, S. L. TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation. J. Immunol.
157: 625-635, 1996.
Koch, S., Muralidhar, G. and Swain, S.L. Both naive and memory CD4 T cell subsets become anergic during MAIDS and each subset can sustain disease. J. Immunol. 152:5548-5556, 1994.
Muralidhar, G., Koch, S. and Swain, S.L. CD4 T cell subsets and superantigen in MAIDS. In: Alcohol, Drugs of Abuse and Immunomodulation, Advances in the Biosciences Vol. 86, R.R. Watson (Ed.), Pergamon Press, Great Britain, pp. 289-297, 1993.
Muralidhar, G., Sepulveda, H., Feeney, A., Riblet, R. and Dutton, R.W. V gene specific regulation of immunoglobulin gene expression. I. Igh V gene usage in the response to the ese epitope on ‘Hi’ SRBC. J. Immunol. 149:3574-3579, 1992.
Muralidhar, G., Koch, S., Haas, M. and Swain, S.L. CD4 T cells in murine acquired immuno-deficiency syndrome: Polyclonal progression to anergy. J. Exp. Med. 175:1589-1599, 1992.
Denich, K., Crain, A., Rugo, H., Muralidhar, G., and O'Hanley. Frequency and organization pap A homologous DNA sequences among uropathogenic Digalactoside-binding Escherichia coli strains. Infection and Immunity, 2089-2096, 1991.
Muralidhar, G., Ochieng, J. and Trewyn, R.W. Altered queuine modification of transfer RNA associated with in vitro transformation of Chinese hamster embryo cells. Cancer Res. 49:7110-7114, 1989.
Muralidhar, G., Utz, E.D., Elliott, M.S., Katze, J.R., and Trewyn, R.W. Identifying inhibitors of queuine modification of tRNA in cultured cells. Analytical Biochem. 171:346-351, 1988.
Muralidhar, G., and Trewyn, R.W. Enhancement of the chemical transformation of Chinese hamster embryo cells in vitro by 7-methylguanine. Cancer Res. 47:2440-2444, 1987.
Trewyn, R.W., Kretz, K.A., Utz, E.D. Patrick, D.E., and Muralidhar, G. Hematopoiesis and the inosine modification in transfer RNA. Proc. Society of Expt. Biol. and Medicine 179:497-503, 1985.
Manuscripts in preparation/submitted
Muralidhar, G., Pandit T., Yates, C, Rao, Rama, Adenoviral capsid-mediated immune modulation regulates allergen-induced asthma
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cell-based vaccine for atherosclerosis.
Muralidhar, G., Nandana, KS, Ghori, A., Chataraj, P and Kakkar, V. Dendritic cells and cytokines in CAD patients: Implications for Vaccine development.
References
Will be provided upon request
