Daniela F Hernandez, MA, MPhil

Job title:
PhD candidate
Organization:
Columbia University
PD Guide Terms:
Clinical & Biological Features
Therapeutic Development
Contributions:
Published Contributions:
Dopamine, Alpha-synuclein, and autophagic cell death
How can oxidative stress contribute to alpha-synuclein pathology/toxicity? What oxidative modifications of alpha-synuclein are relevant to the PD pathogenic process?
4 Feb 2010 12:10 PM EST
Elevated cytosolic DA levels have been shown to result in increased neurotoxicity in cellular models of PD (Mosharov et al., 2009). In a new study published in the Journal of Neuroscience Research, ... 
Q&A with Dr. Cristina Malagelada -- Rapamycin protects against neuronal cell death
Hot Topics@SfN 2009
26 Jan 2010 01:50 PM EST
In a new paper published in the Journal of Neuroscience, Malagelada et al. demonstrate that rapamycin can prevent neuron cell death in in vitro and in vivo models of  PD. Previously highlighted ... 
Beclin-1 gene delivery and autophagy
Autophagy in neurodegeneration: fire-fighter and/or incendiarist?
7 Dec 2009 02:22 PM EST
Given that autophagy has been implicated in a several neurodegenerative disorders, including PD, targeting this pathway, may be a possible therapeutic strategy.  In a recent paper, Spencer et ... 
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