Mark Cookson, PhD

Job title:
Chief Investigator
Organization:
National Institute of Health
National Institute on Aging
PD Guide Terms:
Genetic Factors
Pathogenic Mechanisms
Contributions:
Published Contributions:
How does LRRK2 drive PD pathology?
What is the relationship between LRRK2 and synuclein? And Tau?
8 May 2009 05:41 PM EST
Of the various genetic forms of parkinsonism, two dominant genes stand out due to their relevance for the majority of Parkinson’s disease (PD) cases. a-Synuclein is important because the ... 
Responses: 1
Caution needed when using ambiguous genetic variants
New Research: Transcriptional repression of p53 by parkin
5 Oct 2009 09:21 AM EST
Nuclear accumulation of parkin is prominent when the protein is expressed in cells.  Alves da Costa suggest that this nuclear pool suppresses p53 and that this is responsible for the anti-cell ... 
Comment on “A Neurotoxic Phosphoform of Elk-1 Associates with Inclusions from Multiple Neurodegenerative Diseases” by Sharma et al
A neurotoxic phosphoform of elk-1 associates with inclusions from multiple neurodegenerative diseases.
8 Feb 2010 04:18 PM EST
The data from Sharma et al is suggestive of a pro cell death role of Elk1 that has been phosphorylated at T417.  Antibodies against p-T417 Elk1 identify inclusions in a variety ... 
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