Vulnerable Dendrites and Synapses in Aging and Alzheimer’s Disease (R01)

The purpose of this initiative is to solicit research proposals that will investigate the factors regulating synaptic plasticity and dysfunction with a particular emphasis on the age-dependent changes in the functions of dendrites, spines and synapses of key cell types in regions of brain that are selectively vulnerable in certain neurodegenerative disorders such as AD, or with aging using, for example, in vitro and in vivo models.

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