Funding Opportunity

PD Objective Measures

Clinical Scales, Motor Symptoms
Institution: 
The Kinetics Foundation
Announcement date: 
12 Jun 2010
Submission deadline: 
01 Aug 2010

 

 

Help test the value of objective measurements for PD, and receive free equipment and support for your trial or study!

Measurements that are both objective and precise are in critical need in the development of new treatments for Parkinson's Disease, particularly with the evaluation of neuroprotective therapies.

The Kinetics Foundation has supported the development and validation of the OPDM (Objective Parkinson's Disease Measurement) System, consisting of two different input devices and a back-end data server, and is now making these integrated systems available to the research community. The system was developed and validated at Academic Centers including Oregon Health Science University and Portland State University and have been used at a number of supporting institutions including the NIH, UCSF, and Rush University Medical Center; created in part through collaboration with Intel.

Call to Action: While the OPDM system has shown good promise, it is new to the Parkinson's community at large. The Kinetics Foundation has offered to provide free systems, as well as some funds for third party costs of patient participants. Their goal is to accelerate the adoption of objective measurement devices by providing the OPDM System to studies and trials that would benefit from features like increased precision and more frequent measurements.

Systems are limited, so those wishing to receive them must submit a brief online application, explaining how their study would benefit from using the system, and agree to publicly share the results they obtain from the use of the devices (e.g. journal publication, pdonlineresearch.org).

The OPDM-Dexterity can be used in clinic and/or at home, the OPDM-Mobility is clinic-only; any proposed combination of devices and locations will be considered.

We will have representatives at the MDS Congress in Buenos Aries; for more information, including how to apply, contact OPDM@kineticsfoundation.org. Please include information regarding your trial, including the number of subjects you would like to test. More information will be made available online by July 1, 2010. Submissions will be due by August 1, 2010. Winners of these systems, and the financial support that accompanies them, will be announced by September 1, 2010.

 

Figure 1. The first test, OPDM-Dexterity, is taken by the patient on a device resembling a notebook computer (above). The patient takes a simple five minute upper extremity test after a brief video instruction. The system automatically calculates an OPDM Score (calibrated to the UPDRS Motor Score) and logs the patient's scores at the OPDM-Server.

 

 

 

 

 

 

Figure 2: The second test, OPDM-Mobility, is taken by the patient while wearing accelerometers on wrists/ankles/sternum/sacrum. This data is collected in-clinic. The patient performs the OPDM-Mobility test, as normally administered as part of the Motor UPDRS, and the system automatically calculates scores including turning duration, stride velocity, and peak arm speed and uploads the data to the OPDM-Server.

 

 

 

 

 

Reference Publications:

  • iTUG, a Sensitive and Reliable Measure of Mobility, A. Salarian, F. B. Horak, C. Zampieri, P. Carlson-Kuhta, J. G. Nutt, and K. Aminian, IEEE Transactions on Neural Systems andRehabilitation Engineering, in press.
  • An instrumented timed up and go test characterizes gait and postural transitions in untreated Parkinson’s disease, C. Zampieri, A. Salarian, P. Carlson-Kuhta, K. Aminian, J. G. Nutt, and F. B. Horak, Journal of Neurology, Neurosurgery, andPsychiatry, vol. 81, issue 2, pp. 171-176, Feb. 2010
  • Analyzing 180° turns using an inertial system reveals early signs of progression ofParkinson's disease, A. Salarian, C. Zampieri, F. B. Horak, P. Carlson-Kuhta, J. G. Nutt, and K. Aminian, inEngineeringin Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE, 2009, pp. 224-227.
  • Testing objective measures of motor impairment in early Parkinson’s disease: Feasibility study of an at-home testing device  Christopher G. Goetz, Glenn T. Stebbins, David Wolff, William DeLeeuw, Helen Bronte-Stewart, Rodger Elble, Mark Hallett, John Nutt, Lorraine Ramig, Terence Sanger, Allan D. Wu, Peter H. Kraus, Lucia M. Blasucci, Ejaz A. Shamim, Kapil D. Sethi, Jennifer Spielman, Ken Kubota, Andrew S. Grove, Eric Dishman, C. Barr Taylor, in Movement Disorders, vol. 24, issue 4, pp. 551-556, Dec. 2008
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