Contributions

PDD and DLB: insight from pathology and genetics?
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo.
Charleen T Chu, PITT
16 Mar 2010 04:50 PM EST
The relationship of Parkinson disease with dementia (PDD) and Dementia with Lewy bodies (DLB) is obviously an important conceptual issue for studies involving post-mortem tissues (DLB/PDD working ... 
Aging and PD
MEMBERS' OPEN FORUM: for rapid-fire posting of your questions and comments.
Brian K. Fiske, MJFF
16 Mar 2010 03:49 PM EST
Dr. Mastroberardino asks a really great and fundamental question I think. This is something I've been curious about for a while: Is PD simply an exaggeration of an aging process (or inability to deal ... 
Breakout Group: Biomarkers
MJFF 2010 Scientific Advisory Board Meeting
Mark Frasier, MJFF
16 Mar 2010 02:37 PM EST
MJFF has invested over $24 million in the identification and optimization of biomarkers that will assist investigators in the diagnosis and tracking the progression of Parkinson's disease. The ... 
Phosphorylation of a-synuclein at S87: Commentary on Paleologou et al. (2010)
POWs: Papers of the Week
Ayse Ulusoy, Lund, et al.
16 Mar 2010 02:34 PM EST
The majority of a-synuclein within Lewy bodies (LB) in PD brains and related synucleinopathies is phosphorylated. Phosphorylation of the serine residue at position 129 (S129) has been found in ... 
The influence of aging on PD: research priorities in the next decade
MEMBERS' OPEN FORUM: for rapid-fire posting of your questions and comments.
Pier G Mastroberardino
16 Mar 2010 11:56 AM EST
Aging is the major risk factor for PD, and research efforts should not disregard this fundamental component of the pathogenesis. ... 
Responses: 1
L-DOPA-induced dyskinesia (LID) can be difficult to quantify...
Which behavioral outcomes are relevant in rodent models of dyskinesia?
M. Angela Cenci, Lund
16 Mar 2010 10:12 AM EST
L-DOPA-induced dyskinesia (LID) can be difficult to quantify in all species, primates and rodents alike. In their most common form, dyskinesias appear in the “on” phase of the L-DOPA ... 
MJFF SAB 'Fastfire' Session
MJFF 2010 Scientific Advisory Board Meeting
Brian K. Fiske, MJFF
15 Mar 2010 04:37 PM EST
During an open forum discussion at the 2010 MJFF Annual Scientific Advisory Board meeting, members made the following recommendations for potential further activities and priorities for the PD ... 
Breakout Group: Data and Tool Sharing
MJFF 2010 Scientific Advisory Board Meeting
Alison Urkowitz, MJFF
15 Mar 2010 04:34 PM EST
The goal of this breakout group was to: ... 
Breakout Group: Clinical Trial Recruitment
MJFF 2010 Scientific Advisory Board Meeting
Sohini Chowdhury, MJFF
15 Mar 2010 04:21 PM EST
Beginning in 2010 MJFF will increase its focus on addressing the issue of clinical study participation.  Many clinical studies face significant hurdles in meeting recruitment goals ... 
Breakout Group: Research Models
MJFF 2010 Scientific Advisory Board Meeting
Kirsten Carlson, MJFF
15 Mar 2010 04:18 PM EST
The primary goal of this breakout group was to prioritize the best rodent models for MJFF to generate or replicate in 2010 in order to make widely available to the research community, unhindered by ... 
POWs: March 9-15, 2010
POWs: Papers of the Week
PDOR Administrator, MJFF
15 Mar 2010 02:12 PM EST
1: Ravina B, Deuel L, Siderowf A, Dorsey ER. Local institutional review board(IRB) review of a multicenter trial: Local costs without local context. Ann ... 
Orolingual dyskinesia in relevance to behavior outcome in mice
Which behavioral outcomes are relevant in rodent models of dyskinesia?
Danqing Xiao
14 Mar 2010 09:45 PM EST
I think abnormal involuntary movements involving opening and closing of mouth (orolingual dyskinesia) and limb will be most relevant behaviorial outcome for rodent dykinesia, evidenced in studies by ... 
tangles and Lewy bodies may be two sides of the same coin
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo.
Thomas G Beach, Sun Health
12 Mar 2010 06:08 PM EST
First, you have to realize that the clinical diagnosis of DLB is only about 50% accurate overall. This may be better in situations where the clinical syndrome of DLB is all there in spades but even ... 
Support for the view that DLB and PDD are similar pathophysiological disease entities
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo.
David Brooks, Imperial
10 Mar 2010 03:24 PM EST
There is still an on-going debate concerning whether Parkinson disease with dementia (PDD) and dementia with Lewy bodies  (DLB) are distinct entities. Clinically, both conditions can be ... 
Responses: 2
Other opinions on the GIGYF2 link to PD?
POWs: Papers of the Week
Brian K. Fiske, MJFF
9 Mar 2010 07:18 PM EST
Thanks to Mark Cookson and Matt Farrer for their quick replies to this question about the link between GIGYF2 and PD. If others have thoughts (or data!) to further clarify this issue, I invite you to ... 
GIGYF2 is a red herring
PARK11
Matthew Farrer, Mayo Clinic
9 Mar 2010 04:30 PM EST
GIGYF2 was nominated as a candidate genes as it falls within PARK11 but the original report lacked evidence of mutation segregation with disease (Launtier et al., 2008). Nor have ... 
No
POWs: Papers of the Week
Mark Cookson, NIH
9 Mar 2010 04:14 PM EST
Well, "no" might be a bit strong, but I think the balance of evidence says not.  Since the original report, there are just too many subsequent studies (referenced by Wang et al) where originally ... 
Help me design a LRRK2 study?
LRRK2 Summit
Brian K. Fiske, MJFF
8 Mar 2010 04:17 PM EST
As an outcome from our December 2009 LRRK2 Summit and various follow-up discussions, there are clearly a number of basic questions around LRRK2 function that remain unanswered (or only partially ... 
POWs: March 1-7, 2010
POWs: Papers of the Week
PDOR Administrator, MJFF
8 Mar 2010 03:00 PM EST
1: Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N, Bar-ShiraA, Belarbi S, Hecham N, Pollak P, Ouvrard-Hernandez AM, Bardien S, Carr J, ... 
Responses: 1
Is GIGYF2 a PD gene or not?
POWs: Papers of the Week
Brian K. Fiske, MJFF
8 Mar 2010 01:14 PM EST
The report from Wang et al identifying variants of GIGYF2 (PARK11) in Chinese PD patients seems to bring back a gene that I had assumed was no longer considered a genetic factor involved in PD (see ... 
Responses: 2