31 Li, Yanping Liu, Wencheng Oo, Tinmarla F Wang, Lei Tang, Yi Jackson-Lewis, Vernice Zhou, Chun Geghman, Kindiya Bogdanov, Mikhail Przedborski, Serge Beal, M Flint Burke, Robert E Li, Chenjian 2009 Nature neuroscience 2009 Jun 7 Nat. Neurosci. http://www.ncbi.nlm.nih.gov/pubmed/19503083?dopt=Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.