MJFF-Generated Resources
MJFF recognizes the fact that scientific research is reliant on the presence of and access to high-quality research tools. To address this need and speed PD research, the Foundation is generating resources for the entire community to use. Below is a list of ongoing projects.
Antibodies
Several LRRK2 antibodies have been generated, and PD researchers have tested five different antibody clones. Antibodies are available for purchase through the Epitomics catalog. Additionally, MJFF worked with Neuromab to generate a mouse monoclonal antibody against LRRK2. This antibody is currently available through the Neuromab catalog. Finally, in June, 2011 MJFF announced the release of a new monoclonal antibody generated in LRRK2-knockout mice. These are available through Covance.
- Follow the discussion
- Purchase antibodies at Epitomics
- Purchase antibodies at Neuromab
- Purchase antibodies at Covance
The generation of phospho-specific LRRK2 antibodies has just begun. Please continue to check back for additional information regarding these antibodies.
PINK1
PINK1 antibodies are still in the planning stages. Please continue to check back for additional information regarding these antibodies.
- The discussion will start soon!
MJFF has driven efforts to produce animal models to further advance our understanding of PD and provide effective translatable tools for drug discovery. These initiatives have included funding the generation of new mouse transgenic/knockout models at Taconic and rat knockout models at Sigma. MJFF also has made significant efforts to have the various rodent transgenic models easily available for distribution to the scientific research community via Taconic and Jackson Laboratories.
MJFF is also funding the characterization of new and existing models at various CROs. Specifically, Wil Research will characterize behavioral phenotypes and biochemistry (striatal levels of neurotransmitters), and NSA labs will characterize the pathological and stereological data using immunohistochemistry.
- View models with projected dates of availability and vendor name
- View details of phenotypic characterization efforts
- View MJFF-generated data
If you have any questions regarding MJFF-driven animal models projects, please contact Kuldip Dave at kdave@michaeljfox.org.
View other PD Online Research resource information:
| Attachment | Size |
|---|---|
| MJFF Characterization Efforts | 179.52 KB |
| All_Animal_Models_07_27_11.pdf | 134.44 KB |
| MJFF Animal Models Data - Aug3.pdf | 812.56 KB |
| MJFF Animal Models Data - Oct 31.pdf | 320.85 KB |
| Characterization Data Feb20_12.pdf | 1.04 MB |
